Protein Info for ABIE51_RS17210 in Lysobacter sp. OAE881

Annotation: nucleoside hydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01156: IU_nuc_hydro
  • amino acids 6 to 299 (294 residues), 291.3 bits, E=5.6e-91

Best Hits

KEGG orthology group: K01239, purine nucleosidase [EC: 3.2.2.1] (inferred from 74% identity to xcb:XC_0946)

Predicted SEED Role

"Inosine-uridine preferring nucleoside hydrolase (EC 3.2.2.1)" in subsystem Purine conversions or Queuosine-Archaeosine Biosynthesis (EC 3.2.2.1)

MetaCyc Pathways

• purine nucleotides degradation I (plants) (10/12 steps found)
• adenosine nucleotides degradation I (7/8 steps found)
• guanosine nucleotides degradation II (4/4 steps found)
• superpathway of guanosine nucleotides degradation (plants) (5/6 steps found)
• adenine and adenosine salvage II (2/2 steps found)
• guanine and guanosine salvage II (2/2 steps found)
• guanosine nucleotides degradation I (3/4 steps found)
• superpathway of purines degradation in plants (10/18 steps found)

KEGG Metabolic Maps

• Nicotinate and nicotinamide metabolism
• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.2.2.1

Protein Sequence (310 amino acids)

>ABIE51_RS17210 nucleoside hydrolase (Lysobacter sp. OAE881)
MNKIPLLIDTDPGVDDALALLMAFNDPRHEVVGLTIAAGNVGLKHTVANALKLCEVAGIE
APVFAGCPGPLLHPAPDAGYVHGQDGFGDVGYEPAQRAAEREHAAQAILRLSHEHAGKLL
LVALGPLTNVALALKLDPTLPDRVARIVVMGGAVTGHGNITPAAEFNVYFDPEAAHIVFE
AFPQIDLADWEGTIAHGLLHDHVVEWLAADSPRARFYERISKKTREWSADRRGDYWHSAD
ALAMAYALEPGGATELVDRPVVVELGHGHARGMTVVDWNRQNGLPDRFRILMRYDQARFE
GLIRAALAAG