Protein Info for ABIE51_RS16015 in Lysobacter sp. OAE881

Annotation: aspartate carbamoyltransferase catalytic subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02729: OTCace_N
  • amino acids 8 to 149 (142 residues), 128.1 bits, E=3e-41
• TIGR00670: aspartate carbamoyltransferase
  • amino acids 8 to 305 (298 residues), 282.9 bits, E=1.4e-88
• PF00185: OTCace
  • amino acids 157 to 303 (147 residues), 89.9 bits, E=1.9e-29

Best Hits

Swiss-Prot: 77% identical to PYRB_STRM5: Aspartate carbamoyltransferase (pyrB) from Stenotrophomonas maltophilia (strain R551-3)

KEGG orthology group: K00609, aspartate carbamoyltransferase catalytic subunit [EC: 2.1.3.2] (inferred from 77% identity to smt:Smal_0942)

Predicted SEED Role

"Aspartate carbamoyltransferase (EC 2.1.3.2)" in subsystem De Novo Pyrimidine Synthesis (EC 2.1.3.2)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (44/46 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (18/18 steps found)
• superpathway of pyrimidine ribonucleotides de novo biosynthesis (9/9 steps found)
• UMP biosynthesis I (6/6 steps found)
• UMP biosynthesis II (6/6 steps found)
• UMP biosynthesis III (5/6 steps found)

KEGG Metabolic Maps

• Alanine and aspartate metabolism
• Pyrimidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.1.3.2

Protein Sequence (307 amino acids)

>ABIE51_RS16015 aspartate carbamoyltransferase catalytic subunit (Lysobacter sp. OAE881)
MNNTHLPRHLLTLDGLPYDALDALLTRAQAFADGHYDRRALDGIAVCTLFFEPSTRTRMS
FTLAAQRLGADVLNFDASTSSTRKGETALDTLKNLEAMGVRGFVIRHHEDGAVAALSQHV
EHGTALVNAGDGRSAHPTQGLLDMLTLRQAKGHDFSKLKVAIVGDVKHSRVARSDLQALR
TLGTGEIRVCGPASLLPDDGTLDGCVVSHDLDAALDGVDAAMMLRLQRERMEEGLVASLD
DYHREFGLTAQRLTRAAPDAVVMHPGPINRGVEITDEVADGPQSLILRQVSNGVAVRMAV
LEALLRG