Protein Info for ABIE51_RS15655 in Lysobacter sp. OAE881
Annotation: bifunctional aspartate kinase/diaminopimelate decarboxylase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K12526, bifunctional diaminopimelate decarboxylase / aspartate kinase [EC: 2.7.2.4 4.1.1.20] (inferred from 72% identity to sml:Smlt1168)Predicted SEED Role
"Aspartokinase (EC 2.7.2.4) / Diaminopimelate decarboxylase (EC 4.1.1.20)" in subsystem Lysine Biosynthesis DAP Pathway or Threonine and Homoserine Biosynthesis (EC 2.7.2.4, EC 4.1.1.20)
MetaCyc Pathways
- superpathway of L-isoleucine biosynthesis I (13/13 steps found)
- superpathway of L-threonine biosynthesis (6/6 steps found)
- L-lysine biosynthesis I (8/9 steps found)
- superpathway of L-methionine biosynthesis (by sulfhydrylation) (10/12 steps found)
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (14/18 steps found)
- aspartate superpathway (19/25 steps found)
- L-homoserine biosynthesis (3/3 steps found)
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (11/15 steps found)
- dipicolinate biosynthesis (3/4 steps found)
- L-lysine biosynthesis III (5/7 steps found)
- L-lysine biosynthesis VI (5/7 steps found)
- L-lysine biosynthesis II (6/9 steps found)
- superpathway of S-adenosyl-L-methionine biosynthesis (6/9 steps found)
- superpathway of L-methionine biosynthesis (transsulfuration) (6/9 steps found)
- superpathway of L-homoserine and L-methionine biosynthesis (5/8 steps found)
- L-methionine biosynthesis IV (2/4 steps found)
- spermidine biosynthesis II (2/4 steps found)
- ectoine biosynthesis (2/5 steps found)
- chorismate biosynthesis II (archaea) (7/12 steps found)
- 3-dehydroquinate biosynthesis II (archaea) (3/7 steps found)
- norspermidine biosynthesis (2/6 steps found)
- cremeomycin biosynthesis (2/7 steps found)
- grixazone biosynthesis (2/8 steps found)
- superpathway of polyamine biosynthesis III (2/8 steps found)
- platensimycin biosynthesis (6/26 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
- Biosynthesis of plant hormones
- Glycine, serine and threonine metabolism
- Lysine biosynthesis
Isozymes
Compare fitness of predicted isozymes for: 2.7.2.4, 4.1.1.20
Use Curated BLAST to search for 2.7.2.4 or 4.1.1.20
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (857 amino acids)
>ABIE51_RS15655 bifunctional aspartate kinase/diaminopimelate decarboxylase (Lysobacter sp. OAE881) MAEANRWVVLKFGGTSVSRRNRWDTIGRLAGKRMADEGVRVLVVVSALSGVTNELQAIAN GDDVDARIAALVERHRAFCGELDLDADTVLGERLAALQALGTDARVATRPLDWQAEVLAQ GELLSSTLGAAYLRSQGLDFGWCDARDWLDAVSLPNASAWSQRLSVNCRLDSDGFGERFS TQPTRALITQGFISRHGDGSTAILGRGGSDTSAAYFGALLKAQRVEIWTDVPGMFSANPR DVPEARLLTRLHYAEAQEIATTGAKVLHPRSIAPCRDAGVPMAILDTERPELPGTRIDAT AATVPGVKAISRRNGIVLVSMESIGMWQQVGFLADVFERFKRHGLSIDLIGSSETNVTVS LDPSENLVTTNVLEALSADLAEICRVKVIAPCAAITLVGRGMRSLLHRLSDIWATFGRQH VHLISQSSNDLNLTFVIDEADAEGLLPHLHAELIRSRAMPVRDATVFGPSWREIAFGAPQ RAPAWWRGRREQLLSLAAHGTPRYVYDLATVRDRARSLSATNAVDRCFYAIKANPHPEIL RTLVGEGFGLECVSQGEFDHVFATLPHITPSRVLFTPSFAPRREYEAAFERGIIVTLDNI EALQRWPEVFKGRTTWLRIDLGHGEGHHEKVKTGGVAAKFGLPMTRFDAFVEEARKLGIR ISGLHAHLGSGIEDPQHWRGVYAHLAGLADGIGTIETIDIGGGLPIPYTPEAPQFDLPLW RAGLEEIKAAYPRYGLVIEPGRYLVAESGALLLTTTQVVEKDGVRRVGCDGGMNALMRPA MYEAYHGIFNLSRDGDTAVFDVVGPICESSDVIGRGRTLPADTAEGDVILVADAGAYGMA MANTYNLRALPAEEAIE