Protein Info for ABIE51_RS15390 in Lysobacter sp. OAE881

Annotation: 5-(carboxyamino)imidazole ribonucleotide synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01161: phosphoribosylaminoimidazole carboxylase, ATPase subunit
  • amino acids 3 to 354 (352 residues), 369.1 bits, E=1.4e-114
• PF02222: ATP-grasp
  • amino acids 107 to 278 (172 residues), 192.8 bits, E=3.6e-61
• PF17769: PurK_C
  • amino acids 305 to 354 (50 residues), 48 bits, 8.1e-17

Best Hits

KEGG orthology group: K01589, 5-(carboxyamino)imidazole ribonucleotide synthase [EC: 6.3.4.18] (inferred from 78% identity to xal:XALc_1273)

Predicted SEED Role

"Phosphoribosylaminoimidazole carboxylase ATPase subunit (EC 4.1.1.21)" in subsystem De Novo Purine Biosynthesis (EC 4.1.1.21)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (44/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (24/26 steps found)
• inosine-5'-phosphate biosynthesis I (6/6 steps found)
• inosine-5'-phosphate biosynthesis II (5/5 steps found)
• inosine-5'-phosphate biosynthesis III (5/6 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 4.1.1.21

Use Curated BLAST to search for 4.1.1.21 or 6.3.4.18

Protein Sequence (379 amino acids)

>ABIE51_RS15390 5-(carboxyamino)imidazole ribonucleotide synthase (Lysobacter sp. OAE881)
MTTVGILGGGQLARMLALSGAPLGLRFLVMDNVADACAGQFAPMVVGDYRDEATLSEFAS
RVDVATFDFENVPAESAQWLSERVPVFPNPGALATAQDRLAEKTLFRELGIPVPPFAPID
TREQLDAALAEIGTPCILKTRRLGYDGKGQFRIKSPADADAAWDALGAQAPKVGLILEGF
VHFQRELSVVAVRGRDGEFRAWPLTENWHVDGVLSASLAPARVDTALGEIAYDYARRLAE
AMDYVGVFALELFCRDGELLANELAPRVHNSGHWTIEGSETSQFQNHLRAVLGLPLGDTR
MVGLACMLNWIGEMPDALPMLREPGGHWHDYGKLPRAGRKVGHATLRADDANALTMSLER
VGLALGREAQVAPVVEALR