Protein Info for ABIE51_RS14345 in Lysobacter sp. OAE881

Annotation: aminomethyl-transferring glycine dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 963 transmembrane" amino acids 331 to 351 (21 residues), see Phobius details amino acids 749 to 767 (19 residues), see Phobius details PF02347: GDC-P" amino acids 18 to 438 (421 residues), 613 bits, see alignment E=4.5e-188 amino acids 443 to 741 (299 residues), 49.1 bits, see alignment E=6.3e-17 TIGR00461: glycine dehydrogenase" amino acids 19 to 950 (932 residues), 1478 bits, see alignment E=0 PF21478: GcvP2_C" amino acids 778 to 899 (122 residues), 201.1 bits, see alignment E=6.5e-64

Best Hits

KEGG orthology group: K00281, glycine dehydrogenase [EC: 1.4.4.2] (inferred from 60% identity to aha:AHA_1720)

Predicted SEED Role

"Glycine dehydrogenase [decarboxylating] (glycine cleavage system P protein) (EC 1.4.4.2)" in subsystem Glycine and Serine Utilization or Glycine cleavage system or Photorespiration (oxidative C2 cycle) (EC 1.4.4.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.4.4.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (963 amino acids)

>ABIE51_RS14345 aminomethyl-transferring glycine dehydrogenase (Lysobacter sp. OAE881)
MSQKTSLRALEHHDAFLERHIGPNDAEIAQMLGVVGFDSLDAMTDAIVPASIKSPKPLDL
PAPITEVEAIAKIRAIADKNQVFKSFIGQGYYGTHTPNVILRNILENPAWYTAYTPYQAE
ISQGRMEALINFQTMCAELTGMEIANASLLDEATAAAEAMTLAKRSAKSKSNTFFVSNGV
HPQTLEVLRTRAEPLEIELVVADDNEAASIDSFGVLLQYPNTFGQIHDYKALADSVHARG
GLVAVATDLLALTLIAAPGEWGADIVVGNTQRFGVPFGFGGPHAAFMACRDAYKRSMPGR
LIGVSIDAEGKAAYRLTLQTREQHIRREKATSNICTAQVLLAVMASMYAVYHGPDGLQRI
ARRTHRLASILATALRNAGITVGPDFFDTLHVVDVDADAIHAKAVDARINLRRIDGRSLG
ISLDETTTRADVVALAALFGAKVDVDALDAIVEDALPNGLLRTSAFLTHPVFNTHHSEHE
LLRYMRSLADKDLAMDRTMIPLGSCTMKLNATAEMIPVTWPEFGNLHPLAPGAQAAGYQR
LIGELEAMLVECTGYDAVSLQPNSGAQGEYAGLLAIRAYHRSRGEAHRDICLIPDSAHGT
NPASAQMCGMQVVVTKTDGNGNVDVEDIRRNAEKYSDRLAAIMMTYPSTHGVFEEEVVEI
CEIIHKHGGQVYTDGANMNALVGVAKPGKWGSDVSHLNLHKTFCIPHGGGGPGVGPCAVK
SHLAPFLPGALNADGVKTDGVGNGDVGMVSAASFGSASILPISWMYVTMMGAAGLRRATQ
VALLNANYIARRLAPHYETLYTGRNDLVAHECILDLRPLKDSTGVSAEDVAKRLIDFGFH
APTLSFPVAGTLMVEPTESESLHELDRFIDAMIQIRDEIRAVEEGKLDREDNPLKNAPHT
ATAVSASEWTHAYPRELAAFPLPSLRLQKYWPPVARVDNVYGDKNVMCACIPVDAYKDDE
VEA