Protein Info for ABIE51_RS14145 in Lysobacter sp. OAE881

Annotation: endopeptidase La

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 812 PF02190: LON_substr_bdg" amino acids 11 to 202 (192 residues), 186.7 bits, see alignment E=1.3e-58 TIGR00763: endopeptidase La" amino acids 13 to 779 (767 residues), 1018.4 bits, see alignment E=0 PF00004: AAA" amino acids 354 to 490 (137 residues), 76.2 bits, see alignment E=8.7e-25 PF07728: AAA_5" amino acids 354 to 478 (125 residues), 35.1 bits, see alignment E=3.2e-12 PF05362: Lon_C" amino acids 578 to 780 (203 residues), 325.6 bits, see alignment E=2.9e-101 PF13541: ChlI" amino acids 621 to 748 (128 residues), 32.3 bits, see alignment E=2.1e-11

Best Hits

Swiss-Prot: 81% identical to LON_XANOR: Lon protease (lon) from Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)

KEGG orthology group: K01338, ATP-dependent Lon protease [EC: 3.4.21.53] (inferred from 83% identity to xal:XALc_0589)

Predicted SEED Role

"ATP-dependent protease La (EC 3.4.21.53) Type I" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent (EC 3.4.21.53)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.21.53

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (812 amino acids)

>ABIE51_RS14145 endopeptidase La (Lysobacter sp. OAE881)
MAVSTEHETLTLPVLPLRDVVVFPHMVIPLFVGRDKSIHALDVAMEADKRILLVAQKSAE
TDDPGADDLYKVGTLAQVLQLLKLPDGTIKVLVEGVSRVNVHDVTERGGALSGQAEVVEP
ESDREEREIEAIARSLMGLFEQYVKTNRKLPPELMQTLSGIDEPGRLADTIAAHLGVRIG
DKQKLLETHGVGARLEQLVGLVDGEIDVQQLEKRIRGRVKSQMEKSQREYYLNEQMKAIQ
KELGEIDDAPNDIDELTRKIAEAGMPKAVEAKAKAELNKLKQMSPMSAEAAVVRNYLDWL
LGVPWKKRTKVRKDLKAAQDVLDADHFGLEKVKDRILEYLAVQSRVKQMKGPILCLVGPP
GVGKTSLGQSIAKATNRKFVRMSLGGVRDEAEIRGHRRTYVGSMPGRIVQNLNKVGSKNP
LFVLDEIDKMSMDFRGDPSSALLEVLDPEQNNAFNDHYLEVDLDLSEVMFVATSNSLNIP
GPLLDRMEVIRIPGYTEEEKLNIAMRYLLPKQIKGNGLKPEELKVAESAVRDIVRYYTRE
SGVRSLEREIAKICRKVVKEIALAGPSKKGAKKNVVNVTSKNLDKYLGVRRYDFGRAEEQ
NEVGLVTGLAWTEVGGDLLQIEATLVPGKGQLLLTGQLGDVMKESASAALSVVRARTEQL
GIDLDFLQKHDVHVHVPEGATPKDGPSAGIAMATALVSMLTRNPVKADVAMTGEITLRGR
VLPIGGLKEKLLAALRGGIRTVIIPEENRKDLADLPKTVTQGLKIIPAKWIDEVLNIALE
RAPTPAPASASGEGETPVRDGSKTVTQTDVKH