Protein Info for ABIE51_RS13725 in Lysobacter sp. OAE881

Annotation: quinone-dependent dihydroorotate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01036: dihydroorotate dehydrogenase (fumarate)
  • amino acids 2 to 339 (338 residues), 411.5 bits, E=1.2e-127
• PF01180: DHO_dh
  • amino acids 45 to 336 (292 residues), 281.9 bits, E=2.8e-88

Best Hits

Swiss-Prot: 74% identical to PYRD_STRMK: Dihydroorotate dehydrogenase (quinone) (pyrD) from Stenotrophomonas maltophilia (strain K279a)

KEGG orthology group: K00226, dihydroorotate dehydrogenase (fumarate) [EC: 1.3.98.1] (inferred from 80% identity to psu:Psesu_1239)

MetaCyc: 52% identical to dihydroorotate dehydrogenase, type 2 (Escherichia coli K-12 substr. MG1655)
Dihydroorotate dehydrogenase. [EC: 1.3.5.2]; 1.3.5.2 [EC: 1.3.5.2]; 1.3.5.2 [EC: 1.3.5.2]

Predicted SEED Role

"Dihydroorotate dehydrogenase (EC 1.3.3.1)" in subsystem De Novo Pyrimidine Synthesis (EC 1.3.3.1)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (44/46 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (18/18 steps found)
• superpathway of pyrimidine ribonucleotides de novo biosynthesis (9/9 steps found)
• UMP biosynthesis I (6/6 steps found)
• UMP biosynthesis II (6/6 steps found)

KEGG Metabolic Maps

• Pyrimidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.3.3.1 or 1.3.5.2 or 1.3.98.1

Protein Sequence (352 amino acids)

>ABIE51_RS13725 quinone-dependent dihydroorotate dehydrogenase (Lysobacter sp. OAE881)
MYGLARPFLFGLDAEAAHGAALNALEVAYRTGAGALLSRRPTPLPTRAFGLTFPNPVGLA
AGLDKNGAHIDALMALGFGFVEIGTVTPRAQEGNPKPRMFRLSEHEAVINRLGFNNGGVD
VLVRNVERAKRRHGLLGINIGKNKDTPNDSAEDDYLFCLERVYPLADYVTVNISSPNTAG
LRELQEEQALRRLVGTLREAQERLAGVHGRRVPMLVKIAPDLTDNDVEAAARVLGDLHVD
GVIATNTTISRVGIEGSPLANEAGGLSGKPLLGQATAVLRMMRTRLPESIPMIGVGGILS
GADAAAKMAAGATLVQCYTGLVYRGPALIKECVEAMRRRKEAPSRGNMPPIV