Protein Info for ABIE51_RS13115 in Lysobacter sp. OAE881

Annotation: Glu/Leu/Phe/Val dehydrogenase dimerization domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02812: ELFV_dehydrog_N
  • amino acids 11 to 130 (120 residues), 115.7 bits, E=1.2e-37
• PF00208: ELFV_dehydrog
  • amino acids 216 to 306 (91 residues), 46.2 bits, E=5.1e-16

Best Hits

Swiss-Prot: 56% identical to DHLE_GEOSE: Leucine dehydrogenase (ldh) from Geobacillus stearothermophilus

KEGG orthology group: K00263, leucine dehydrogenase [EC: 1.4.1.9] (inferred from 73% identity to xcc:XCC1299)

Predicted SEED Role

"Leucine dehydrogenase (EC 1.4.1.9)" in subsystem Branched-Chain Amino Acid Biosynthesis or Leucine Degradation and HMG-CoA Metabolism (EC 1.4.1.9)

KEGG Metabolic Maps

• Valine, leucine and isoleucine biosynthesis
• Valine, leucine and isoleucine degradation

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.4.1.9

Protein Sequence (367 amino acids)

>ABIE51_RS13115 Glu/Leu/Phe/Val dehydrogenase dimerization domain-containing protein (Lysobacter sp. OAE881)
MIFETLDTFGHEQVVFCHNKDAGLKAIIAIHNTVLGPALGGTRMWPYKTEQDALNDVLRL
SRGMTYKNAVAGLNIGGGKAVIIGDPSTDKSEALFRAFGQFVEALGGRYITAEDVGIDVN
DMEYVYRETEYVTGVHQVHGGSGDPSPFTAYGTLQGLMATLNKRFGDEEVGKYSYAVQGL
GHVGMEFVKLLKERGAKIFATDINKGLVDKAVSEYGVEAVGLDEIYDVPADVYSPCALGG
TVNEGTLPRLKAKVICGAANNQLANNAIGDEVAKRGILYAPDYAVNAGGVMNVALELDGY
NRERAMRMMRTIYHNLARIFEIAERDAIPTYRAADRLAEERITAIGKLKLPLGRSAPRFQ
GRIRGGH