Protein Info for ABIE51_RS12425 in Lysobacter sp. OAE881

Annotation: nucleotide sugar dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03026: nucleotide sugar dehydrogenase
  • amino acids 8 to 401 (394 residues), 386 bits, E=9.4e-120
• PF03721: UDPG_MGDP_dh_N
  • amino acids 8 to 181 (174 residues), 115.4 bits, E=3.6e-37
• PF00984: UDPG_MGDP_dh
  • amino acids 203 to 291 (89 residues), 87.4 bits, E=8.7e-29
• PF03720: UDPG_MGDP_dh_C
  • amino acids 318 to 416 (99 residues), 72.5 bits, E=5e-24

Best Hits

Swiss-Prot: 57% identical to VIPA_SALTI: Vi polysaccharide biosynthesis protein VipA/TviB (vipA) from Salmonella typhi

KEGG orthology group: K02474, UDP-N-acetyl-D-galactosamine dehydrogenase [EC: 1.1.1.-] (inferred from 66% identity to abo:ABO_0908)

MetaCyc: 62% identical to UDP-N-acetylgalactosamine 6-dehydrogenase (Pseudomonas aeruginosa)
UDP-N-acetylglucosamine 6-dehydrogenase. [EC: 1.1.1.136]; 1.1.1.136 [EC: 1.1.1.136]

Predicted SEED Role

"UDP-glucose dehydrogenase (EC 1.1.1.22)" in subsystem Lipid A-Ara4N pathway ( Polymyxin resistance ) or Teichuronic acid biosynthesis (EC 1.1.1.22)

MetaCyc Pathways

• UDP-α-D-xylose biosynthesis (2/2 steps found)
• UDP-α-D-glucuronate biosynthesis (from UDP-glucose) (1/1 steps found)
• colanic acid building blocks biosynthesis (8/11 steps found)
• superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis (4/6 steps found)
• UDP-N-acetyl-α-D-galactosaminuronate biosynthesis (1/2 steps found)
• UDP-2,3-diacetamido-2,3-dideoxy-α-D-mannuronate biosynthesis (1/5 steps found)
• UDP-sugars interconversion (3/9 steps found)
• teichuronic acid biosynthesis (B. subtilis 168) (2/9 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (6/24 steps found)

KEGG Metabolic Maps

• Alkaloid biosynthesis I
• Aminosugars metabolism
• Ascorbate and aldarate metabolism
• Benzoate degradation via CoA ligation
• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of type II polyketide products
• Biosynthesis of unsaturated fatty acids
• Bisphenol A degradation
• Butanoate metabolism
• C21-Steroid hormone metabolism
• Fructose and mannose metabolism
• Glycine, serine and threonine metabolism
• Insect hormone biosynthesis
• Linoleic acid metabolism
• Nucleotide sugars metabolism
• Pentose and glucuronate interconversions
• Polyketide sugar unit biosynthesis
• Retinol metabolism
• Starch and sucrose metabolism
• Tetrachloroethene degradation

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.-, 1.1.1.22

Use Curated BLAST to search for 1.1.1.- or 1.1.1.136 or 1.1.1.22

Protein Sequence (425 amino acids)

>ABIE51_RS12425 nucleotide sugar dehydrogenase (Lysobacter sp. OAE881)
MSDSVEIRIAVLGLGYVGLPLAVAFGQRHETIGYDIDDARVARLQTGQDDNGEADVHEIA
AASRLRFVANAAELRTCNVFVVTVPTPVDEHKRPDFRPLVEASRTIGGALKKGDTVIYES
TVYPGATEEICVPELERVSGLTFNQDFFVGYSPERINPGDKQRRLVDIPKVTSGSTPETA
EFVDALYRGIIKAGTHKASSIRVAEASKVIENTQRDANIALVNEFALIFQRLGIDTTEVL
EAAGTKWNFLPFRPGLVGGHCIGVDPYYLIQKAQAAGYYPDILLACRRINDAMGEHVATD
VVKLMIQRDIAVAGSRILILGLTFKENCADLRNTRVVELAQKFGEYRAKVDIHDPWAQAD
EAREAYGIELVAQPPFGAYDAVVLAVAHDQFRELGAKGARAFGKPHALLYDIKSLYPRDE
VDARL