Protein Info for ABIE51_RS12150 in Lysobacter sp. OAE881

Annotation: 3-phosphoserine/phosphohydroxythreonine transaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00266: Aminotran_5
  • amino acids 5 to 349 (345 residues), 166.3 bits, E=5.2e-53
• TIGR01364: phosphoserine transaminase
  • amino acids 5 to 360 (356 residues), 504.9 bits, E=5.5e-156

Best Hits

Swiss-Prot: 78% identical to SERC_XANOR: Phosphoserine aminotransferase (serC) from Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85)

KEGG orthology group: K00831, phosphoserine aminotransferase [EC: 2.6.1.52] (inferred from 78% identity to xom:XOO_2268)

MetaCyc: 55% identical to phosphoserine/phosphohydroxythreonine aminotransferase (Escherichia coli K-12 substr. MG1655)
Phosphoserine transaminase. [EC: 2.6.1.52]; 2.6.1.52 [EC: 2.6.1.52]; Succinyldiaminopimelate transaminase. [EC: 2.6.1.52, 2.6.1.17]

Predicted SEED Role

"Phosphoserine aminotransferase (EC 2.6.1.52)" in subsystem Glycine and Serine Utilization or Pyridoxin (Vitamin B6) Biosynthesis or Serine Biosynthesis (EC 2.6.1.52)

MetaCyc Pathways

• superpathway of sulfate assimilation and cysteine biosynthesis (9/9 steps found)
• L-lysine biosynthesis I (8/9 steps found)
• superpathway of L-serine and glycine biosynthesis I (4/4 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (14/18 steps found)
• aspartate superpathway (19/25 steps found)
• L-serine biosynthesis I (3/3 steps found)
• pyridoxal 5'-phosphate biosynthesis I (5/7 steps found)
• L-cysteine biosynthesis IX (Trichomonas vaginalis) (2/3 steps found)
• superpathway of pyridoxal 5'-phosphate biosynthesis and salvage (6/12 steps found)

KEGG Metabolic Maps

• Glycine, serine and threonine metabolism
• Lysine biosynthesis
• Vitamin B6 metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.6.1.17

Use Curated BLAST to search for 2.6.1.17 or 2.6.1.52

Protein Sequence (361 amino acids)

>ABIE51_RS12150 3-phosphoserine/phosphohydroxythreonine transaminase (Lysobacter sp. OAE881)
MSRAFNFAAGPATLPEAVLRQAQEEMLEWNGVGASIVEISHRGAEFMEVARQAEADLRAL
MSIPDDYAVLFLAGGATLQQALIPLNFAAPGQAADYVVTGHWGKTAIKQARTYVDARIAA
DGESTGFHDIPPRSEWRLTPGAAYVHYTANETIHGVEFRDIPDVGDAPLIADFSSSIAAE
PLDVSRFGVIYGGAQKNLGPVGVTVVIVRRDLLERAGQPRADIMNYSSHVAGESMLNTPP
TWNWYLAGLVFKWMLAEGGVEEFARRNARKSALLYGAIDGSGGFYRNDVVPAARSRMNVP
FFLHDPALDAAFLKESKAAGLLALKGHRVLGGMRASIYNAMPEAGVQALVDFMRDFQKRY
G