Protein Info for ABIE51_RS10790 in Lysobacter sp. OAE881

Annotation: cytochrome c oxidase subunit I

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 625 transmembrane" amino acids 30 to 49 (20 residues), see Phobius details amino acids 73 to 97 (25 residues), see Phobius details amino acids 109 to 130 (22 residues), see Phobius details amino acids 155 to 181 (27 residues), see Phobius details amino acids 193 to 220 (28 residues), see Phobius details amino acids 243 to 264 (22 residues), see Phobius details amino acids 276 to 299 (24 residues), see Phobius details amino acids 313 to 336 (24 residues), see Phobius details amino acids 346 to 368 (23 residues), see Phobius details amino acids 384 to 406 (23 residues), see Phobius details amino acids 421 to 440 (20 residues), see Phobius details amino acids 460 to 483 (24 residues), see Phobius details amino acids 574 to 591 (18 residues), see Phobius details amino acids 597 to 614 (18 residues), see Phobius details TIGR02891: cytochrome c oxidase, subunit I" amino acids 17 to 522 (506 residues), 713.4 bits, see alignment E=7.4e-219 PF00115: COX1" amino acids 26 to 470 (445 residues), 510.2 bits, see alignment E=2.4e-157

Best Hits

Swiss-Prot: 47% identical to COX1_BACPE: Cytochrome c oxidase subunit 1 (ctaD) from Bacillus pseudofirmus (strain OF4)

KEGG orthology group: K02274, cytochrome c oxidase subunit I [EC: 1.9.3.1] (inferred from 65% identity to vap:Vapar_0696)

MetaCyc: 46% identical to cytochrome caa3 oxidase (subunit I) (Bacillus subtilis subtilis 168)
CYTOCHROME-C-OXIDASE-RXN [EC: 7.1.1.9]

Predicted SEED Role

"Cytochrome c oxidase polypeptide I (EC 1.9.3.1)" in subsystem Terminal cytochrome C oxidases (EC 1.9.3.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.9.3.1

Use Curated BLAST to search for 1.9.3.1 or 7.1.1.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (625 amino acids)

>ABIE51_RS10790 cytochrome c oxidase subunit I (Lysobacter sp. OAE881)
MDRLSRSWADRPGFIGWLTTVDHKRVAHRYIVTALVFFALAGVLALIMRTQLATSETRLL
GPDQYNQMFSLHGSAMMFLFAVPIMEAVAVYVVPLMVGTRNISFPRLNAFSYWVYLFGGV
MIFIAFVLDIGPEAGWTGYVPLSSSDFSPGKRTDFWAQMITFTEVAALCIAVEIVATVMT
MRAPGMTLSRIPLFVWSMLVTSFMVIFAMPAVMLASTFLITDRLVGTQFYNPGEGGDPLL
WQHLFWFFGHPEVYIIFMPALGMISSIVETFSRRPIFAYTPMVMALVATGFLAFGLWVHH
MFAAGLPPVGNSFYTAASMLIAVPSGLQIFCWIATIATGRPRFAVPMLFVMGFFALFVLG
GLTGVMLASVPLDLQVHDTYFVVAHFHYVLIGGAVFPLMGALYLWFPKITGRMLGETLGR
WQFWLFFIGFNVTFFPMHYLGLIGMPRRVYTYQPGLGWDVYNFIATLGSYLMAASVLVFV
FNVWRSLRRGEPAADDPWGSPDLMWATTSPPPSYNFEHTPVVTGRHPLWLNAEADPRPDL
PVIAGVRDDRREVLLSTPVDAIPLCRWSMPDPSIWPLWSAVALTVVFVWSIFDQWGVVWG
AIPAAIAFTIWFWPKRSDRSQESDE