Protein Info for ABIE51_RS10635 in Lysobacter sp. OAE881

Annotation: acyl-CoA dehydrogenase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02771: Acyl-CoA_dh_N
  • amino acids 28 to 139 (112 residues), 99.3 bits, E=3.7e-32
• PF02770: Acyl-CoA_dh_M
  • amino acids 143 to 236 (94 residues), 77 bits, E=2e-25
• PF00441: Acyl-CoA_dh_1
  • amino acids 255 to 395 (141 residues), 102.4 bits, E=5.6e-33
• PF08028: Acyl-CoA_dh_2
  • amino acids 264 to 384 (121 residues), 33.6 bits, E=8.9e-12

Best Hits

Swiss-Prot: 47% identical to ACOX4_ARATH: Acyl-coenzyme A oxidase 4, peroxisomal (ACX4) from Arabidopsis thaliana

KEGG orthology group: K00252, glutaryl-CoA dehydrogenase [EC: 1.3.99.7] (inferred from 81% identity to bur:Bcep18194_B1396)

MetaCyc: 47% identical to ACX4 (Arabidopsis thaliana col)
Acyl-CoA oxidase. [EC: 1.3.3.6]; 1.3.3.6 [EC: 1.3.3.6]; 1.3.3.6 [EC: 1.3.3.6]; 1.3.3.6 [EC: 1.3.3.6]

Predicted SEED Role

"Glutaryl-CoA dehydrogenase (EC 1.3.99.7)" (EC 1.3.99.7)

MetaCyc Pathways

• superpathway of glyoxylate cycle and fatty acid degradation (12/14 steps found)
• fatty acid β-oxidation II (plant peroxisome) (4/5 steps found)
• (5Z)-dodecenoate biosynthesis II (4/6 steps found)
• methyl ketone biosynthesis (engineered) (4/6 steps found)
• fatty acid β-oxidation VI (mammalian peroxisome) (4/7 steps found)
• fatty acid β-oxidation VII (yeast peroxisome) (2/5 steps found)
• propanoyl-CoA degradation II (2/5 steps found)
• 6-gingerol analog biosynthesis (engineered) (2/6 steps found)
• fatty acid β-oxidation V (unsaturated, odd number, di-isomerase-dependent) (1/5 steps found)
• 9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast) (2/10 steps found)
• (4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase) (3/13 steps found)
• crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered) (3/14 steps found)
• docosahexaenoate biosynthesis III (6-desaturase, mammals) (3/14 steps found)
• 10-cis-heptadecenoyl-CoA degradation (yeast) (1/12 steps found)
• 10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast) (1/12 steps found)
• jasmonic acid biosynthesis (4/19 steps found)

KEGG Metabolic Maps

• Benzoate degradation via CoA ligation
• Biosynthesis of plant hormones
• Biosynthesis of unsaturated fatty acids
• Fatty acid metabolism
• Lysine degradation
• Tryptophan metabolism
• alpha-Linolenic acid metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.3.99.7

Use Curated BLAST to search for 1.3.3.6 or 1.3.99.7

Protein Sequence (402 amino acids)

>ABIE51_RS10635 acyl-CoA dehydrogenase family protein (Lysobacter sp. OAE881)
MNRHDDTALASALPEANGDFYDFAGALSDEENAIRLKVRAFMEGEVKPIISDYWERDEFP
FELLPGFRALGISGIPFQGYGCTGGSSTLLGFVTMEIARVDSSIATFFGVHGGLAMGSIY
LCGSEEQKQKWLPPMARMETIGSFGLTEPEVGSGAAGGLTTTARREGDTWIINGQKKWIG
NATWGDVTIVWARDVDDNQVKGFIVENRSPGFHVEKILHKMALRVVQNGLITLTDCRVPE
ANRLQGANSFRDTARVLAATRAGVAWESVGCARGAYEYALRYAQRRIQFGKPIASFQLVQ
DLLFRMLCNITSTQAVCVRLSQMQDQGLMRDEHAALAKGLCTVRMRETVGWARELLGGNG
ILLDQQVGRFVADAEALYSYEGTREMNALIVGRAITGFSAFV