Protein Info for ABIE51_RS09855 in Lysobacter sp. OAE881

Annotation: HWE histidine kinase domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 333 TIGR00229: PAS domain S-box protein" amino acids 16 to 138 (123 residues), 47.4 bits, see alignment E=1e-16 PF00989: PAS" amino acids 19 to 130 (112 residues), 38 bits, see alignment E=4.3e-13 PF13188: PAS_8" amino acids 19 to 66 (48 residues), 28.3 bits, see alignment 3.7e-10 PF08448: PAS_4" amino acids 26 to 134 (109 residues), 62 bits, see alignment E=1.8e-20 PF13426: PAS_9" amino acids 33 to 132 (100 residues), 34.4 bits, see alignment E=6.8e-12 PF07536: HWE_HK" amino acids 146 to 228 (83 residues), 98.4 bits, see alignment E=9.9e-32 PF07568: HisKA_2" amino acids 146 to 208 (63 residues), 29.2 bits, see alignment E=2.4e-10

Best Hits

KEGG orthology group: None (inferred from 63% identity to xac:XAC3136)

Predicted SEED Role

"Chemotaxis protein methyltransferase CheR (EC 2.1.1.80)" in subsystem Bacterial Chemotaxis (EC 2.1.1.80)

Isozymes

Compare fitness of predicted isozymes for: 2.1.1.80

Use Curated BLAST to search for 2.1.1.80

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (333 amino acids)

>ABIE51_RS09855 HWE histidine kinase domain-containing protein (Lysobacter sp. OAE881)
MNDLAHAYDPAAASAKLRLYEAIMQATPDLVYVFDLHHRFIYANDALLTMWGRSWDDAIG
KTCLELGYEPWHAAMHDREIEQVIATGRPIRGDVPFPHTTKGVRIYDYIFTPVFDPEGRV
EAIAGTTRDVTERQEHEKHMQLMVNELNHRVKNTLAMVQSLVFQTLDGAPDPDEAREKIE
SRLLALSDAHNILTRENWQGADIADIVEGAASLFQQRAGERFDITGPTAILEPRRTVALA
MALHELCTNAIKHGALSVPGGRVGIHWEFDATRSAVRLHWKETGGPEVTPPTQFGFGSTL
LRRGLKHDLGGEATLAFERDGLRCDIVIPFTSP