Protein Info for ABIE51_RS09475 in Lysobacter sp. OAE881

Annotation: IMP dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01302: inosine-5'-monophosphate dehydrogenase
  • amino acids 8 to 452 (445 residues), 608.3 bits, E=4.4e-187
• PF00478: IMPDH
  • amino acids 8 to 471 (464 residues), 523.9 bits, E=4.6e-161
• PF00571: CBS
  • amino acids 94 to 139 (46 residues), 43.7 bits, 7e-15
  • amino acids 148 to 202 (55 residues), 33.2 bits, 1.3e-11
• PF01070: FMN_dh
  • amino acids 256 to 363 (108 residues), 33.8 bits, E=5.1e-12
• PF01645: Glu_synthase
  • amino acids 276 to 359 (84 residues), 20.7 bits, E=5.1e-08

Best Hits

Swiss-Prot: 68% identical to IMDH_ACICA: Inosine-5'-monophosphate dehydrogenase (guaB) from Acinetobacter calcoaceticus

KEGG orthology group: K00088, IMP dehydrogenase [EC: 1.1.1.205] (inferred from 87% identity to xal:XALc_1580)

MetaCyc: 62% identical to inosine 5'-monophosphate dehydrogenase (Escherichia coli K-12 substr. MG1655)
IMP dehydrogenase. [EC: 1.1.1.205]

Predicted SEED Role

"Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205)" in subsystem Purine conversions (EC 1.1.1.205)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (44/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (24/26 steps found)
• superpathway of purine nucleotide salvage (12/14 steps found)
• superpathway of guanosine nucleotides de novo biosynthesis I (6/6 steps found)
• purine nucleotides degradation I (plants) (10/12 steps found)
• adenosine nucleotides degradation I (7/8 steps found)
• superpathway of guanosine nucleotides de novo biosynthesis II (7/8 steps found)
• guanosine ribonucleotides de novo biosynthesis (4/4 steps found)
• inosine 5'-phosphate degradation (3/4 steps found)
• purine nucleotides degradation II (aerobic) (7/11 steps found)
• ureide biosynthesis (3/7 steps found)
• superpathway of purines degradation in plants (10/18 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Drug metabolism - other enzymes
• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.205

Use Curated BLAST to search for 1.1.1.205

Protein Sequence (485 amino acids)

>ABIE51_RS09475 IMP dehydrogenase (Lysobacter sp. OAE881)
MLRIQAEALTYDDVSLVPAHSTVLPKDVSLTTRLTRDLNIRLPILSAAMDTVSEARLAIA
MAQLGGISIIHKNMSLEAQAAQVAQVKKFEAGVIKEPFTVGPDTTIGEVLKLTRARNISG
VPVVEGGQLMGIVTSRDMRFEKKLDDPVRHIMTKKDRLVTVREGATDEEVLSLLHKHRIE
KVLVVNDGFELRGLITVKDIQKKSDNPNAAYDTSERLLVGAAVGVGGDTEARVEALAAAC
VDVVVVDTAHGHSQGVLDRVNWVKKNFPQLQVIGGNIVTGDAALALMDNGADAVKVGVGP
GSICTTRIVAGVGVPQVTAVAMVAEALQDRIPLIADGGIRYSGDIGKAIVAGASTVMIGG
LFAGTEEAPGEVELFQGRSYKSYRGMGSLGAMEQGSKDRYFQDASDADKLVPEGIEGRVP
YRGPLRNVVHQLAGGLRATMGYVGCASIEDMRKKPSFVRITNAGARESHVHDVQITKEPP
NYRAG