Protein Info for ABIE51_RS09030 in Lysobacter sp. OAE881

Annotation: GDSL-type esterase/lipase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00657: Lipase_GDSL
  • amino acids 34 to 202 (169 residues), 51.3 bits, E=1.7e-17
• PF13472: Lipase_GDSL_2
  • amino acids 37 to 197 (161 residues), 80.9 bits, E=1.7e-26

Best Hits

KEGG orthology group: K10804, acyl-CoA thioesterase I [EC: 3.1.1.5 3.1.2.-] (inferred from 49% identity to psu:Psesu_0737)

Predicted SEED Role

"Arylesterase precursor (EC 3.1.1.2)" (EC 3.1.1.2)

MetaCyc Pathways

• phospholipid remodeling (phosphatidylethanolamine, yeast) (2/4 steps found)

KEGG Metabolic Maps

• Benzoate degradation via CoA ligation
• Biosynthesis of plant hormones
• Biosynthesis of unsaturated fatty acids
• Bisphenol A degradation
• Fatty acid biosynthesis
• Glycerophospholipid metabolism
• Limonene and pinene degradation
• Ubiquinone and menaquinone biosynthesis
• alpha-Linolenic acid metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.1.1.2, 3.1.1.5, 3.1.2.-

Use Curated BLAST to search for 3.1.1.2 or 3.1.1.5 or 3.1.2.-

Protein Sequence (226 amino acids)

>ABIE51_RS09030 GDSL-type esterase/lipase family protein (Lysobacter sp. OAE881)
MRPKFAALLCFALFTASLPALAANRAADASPDTVLIVGDSLSSAHRMEPTQGWVSLLQAR
LATETKTPPAIVNASRGGKTLTDALGELPTLLEQHHPDVVVLELGGNDAILGAKRDAIER
DLSRLIELSRAQGAKVAILGFVVPPAFDKDGSANLLREAYATIAKSADVALLPSLLGDIS
STPALLQDDGIHPNAAAQPRVLDNAWPTLRPLLLGDATVRTSGASK