Protein Info for ABIE51_RS08680 in Lysobacter sp. OAE881

Annotation: homoserine O-acetyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01392: homoserine O-acetyltransferase
  • amino acids 17 to 373 (357 residues), 358.7 bits, E=1.6e-111
• PF00561: Abhydrolase_1
  • amino acids 70 to 358 (289 residues), 59.3 bits, E=2.3e-20

Best Hits

Swiss-Prot: 77% identical to SST_STRMK: Serine O-succinyltransferase (metX) from Stenotrophomonas maltophilia (strain K279a)

KEGG orthology group: K00641, homoserine O-acetyltransferase [EC: 2.3.1.31] (inferred from 77% identity to sml:Smlt3277)

MetaCyc: 65% identical to serine O-acetyltransferase (Streptomyces lavendulae lavendulae)
Serine O-acetyltransferase. [EC: 2.3.1.30]

Predicted SEED Role

"Homoserine O-acetyltransferase (EC 2.3.1.31)" in subsystem Methionine Biosynthesis (EC 2.3.1.31)

MetaCyc Pathways

• superpathway of sulfate assimilation and cysteine biosynthesis (9/9 steps found)
• superpathway of L-methionine biosynthesis (by sulfhydrylation) (10/12 steps found)
• superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) (8/10 steps found)
• L-cysteine biosynthesis I (2/2 steps found)
• superpathway of L-cysteine biosynthesis (fungi) (4/6 steps found)
• L-homocysteine biosynthesis (1/2 steps found)
• L-cysteine biosynthesis VII (from S-sulfo-L-cysteine) (2/4 steps found)
• L-methionine biosynthesis III (2/4 steps found)
• D-cycloserine biosynthesis (3/6 steps found)
• seleno-amino acid biosynthesis (plants) (2/5 steps found)
• N-3-oxalyl-L-2,3-diaminopropanoate biosynthesis (1/4 steps found)
• L-cysteine biosynthesis VI (reverse transsulfuration) (3/7 steps found)
• superpathway of seleno-compound metabolism (5/19 steps found)

KEGG Metabolic Maps

• Cysteine metabolism
• Methionine metabolism
• Sulfur metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.3.1.31

Use Curated BLAST to search for 2.3.1.30 or 2.3.1.31

Protein Sequence (376 amino acids)

>ABIE51_RS08680 homoserine O-acetyltransferase (Lysobacter sp. OAE881)
MTEFIPPGTRWFDLPSPFPMKRGGELHGARVAYETWGTLNAARDNAVLIVTGLSPDAHAA
SNEANPEPGWWEAMLGPGKPIDTNRWFVICVNSLGSCKGSTGPASINPLTGALYRLDFPD
LSVEDGADAAAHLVRGLGLDRIACLIGNSMGGMTALAFLLRHPGLAQHHINISGAAKALP
FSIAIRSLQREAIRLDPNWNHGQYDDAHYPESGMRMARKLGVITYRSALEWDGRFGRVRL
DSDRADEDPFGLEFEVESYLEGHARRFVRRFDPNCYLYLSRSMDWFDIGEYSATRQNGEA
DTRAGLASIRIGKALAIGVHTDILFPLQQQEEIAEGLRAGGAEATFLPLPSPQGHDAFLV
DIARFGPAVEGFLNAL