Protein Info for ABIE51_RS07995 in Lysobacter sp. OAE881

Annotation: 4-hydroxy-tetrahydrodipicolinate synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00701: DHDPS
  • amino acids 3 to 278 (276 residues), 264.1 bits, E=5.3e-83
• TIGR00674: 4-hydroxy-tetrahydrodipicolinate synthase
  • amino acids 5 to 279 (275 residues), 285.6 bits, E=1.6e-89

Best Hits

Swiss-Prot: 71% identical to DAPA_XANAC: 4-hydroxy-tetrahydrodipicolinate synthase (dapA) from Xanthomonas axonopodis pv. citri (strain 306)

KEGG orthology group: K01714, dihydrodipicolinate synthase [EC: 4.2.1.52] (inferred from 71% identity to xcv:XCV1791)

MetaCyc: 44% identical to 4-hydroxy-tetrahydrodipicolinate synthase (Escherichia coli K-12 substr. MG1655)
DIHYDRODIPICSYN-RXN [EC: 4.3.3.7]

Predicted SEED Role

"4-hydroxy-tetrahydrodipicolinate synthase (EC 4.3.3.7)" (EC 4.3.3.7)

MetaCyc Pathways

• L-lysine biosynthesis I (8/9 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (14/18 steps found)
• aspartate superpathway (19/25 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (11/15 steps found)
• dipicolinate biosynthesis (3/4 steps found)
• L-lysine biosynthesis III (5/7 steps found)
• L-lysine biosynthesis VI (5/7 steps found)
• L-lysine biosynthesis II (6/9 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Lysine biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 4.2.1.52, 4.3.3.7

Use Curated BLAST to search for 4.2.1.52 or 4.3.3.7

Protein Sequence (301 amino acids)

>ABIE51_RS07995 4-hydroxy-tetrahydrodipicolinate synthase (Lysobacter sp. OAE881)
MRLSGSITALATPFTASGEIDLDAWNRLLDGQLAAGTQGVVVAGSTGEAAALFDAEYDTL
LRTAVERVAGRIPVLAGTGLSNTAKTIELTRRVAALGADAALVVTPPYVRPTQAGLIAHY
RAIADDGALPVVLYNVPGRTGGDLLPETVAELVSHPRIVGIKEARSEPERMAALLELRSE
EFAILSGDDPTACRAMFAGADGVISVASNVVPRAFRRLADLARAGQRDAALALDARLQTT
YDFLGVEPNPIPVKALLARQGIGHGLRLPLLPLSAAHAGTAATIAALVAELELESHESLV
A