Protein Info for ABIE51_RS06645 in Lysobacter sp. OAE881

Annotation: monovalent cation:proton antiporter-2 (CPA2) family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 608 transmembrane" amino acids 6 to 26 (21 residues), see Phobius details amino acids 34 to 52 (19 residues), see Phobius details amino acids 58 to 77 (20 residues), see Phobius details amino acids 89 to 111 (23 residues), see Phobius details amino acids 117 to 138 (22 residues), see Phobius details amino acids 151 to 172 (22 residues), see Phobius details amino acids 184 to 205 (22 residues), see Phobius details amino acids 220 to 237 (18 residues), see Phobius details amino acids 241 to 259 (19 residues), see Phobius details amino acids 271 to 291 (21 residues), see Phobius details amino acids 296 to 317 (22 residues), see Phobius details amino acids 337 to 356 (20 residues), see Phobius details amino acids 362 to 384 (23 residues), see Phobius details PF00999: Na_H_Exchanger" amino acids 15 to 375 (361 residues), 224.8 bits, see alignment E=1.6e-70 TIGR00932: transporter, monovalent cation:proton antiporter-2 (CPA2) family" amino acids 18 to 287 (270 residues), 264.5 bits, see alignment E=6.1e-83 PF02254: TrkA_N" amino acids 405 to 516 (112 residues), 67.9 bits, see alignment E=1e-22

Best Hits

Swiss-Prot: 52% identical to KEFX_HAEIN: Glutathione-regulated potassium-efflux system protein (kefBC) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K11747, glutathione-regulated potassium-efflux system protein KefB (inferred from 71% identity to sml:Smlt2066)

Predicted SEED Role

"Glutathione-regulated potassium-efflux system protein KefB" in subsystem Glutathione-regulated potassium-efflux system and associated functions

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (608 amino acids)

>ABIE51_RS06645 monovalent cation:proton antiporter-2 (CPA2) family protein (Lysobacter sp. OAE881)
MADAASIDLGKVVALLGVTVVAVPVFRRLGLGSVLGYLAAGLVIGPFGLGWFSDPQAILH
VAELGVVMFLFVIGLEMRPSHLWSLRRQIFGLGTLQIAACTAALTGVGLLFGYEPVVAFI
GAMGFVLTSTAIVMQLLAERGDIALPHGQKIVSVLLFEDLLIVPLLVLVALLAPGEPSSD
ASRWASIGIATGVLLALLAAGIWLLNPLFRLLAAARAREVMTAAALLVVLGSALLMQLGG
LSMAMGAFLAGVLLSESTFRHQLEADVEPFRGLLLGLFFLGVGMALDLSVVRENWMPILG
AVLAMMLVKALCIYAVARLMDSSHHEALDRATLMAQGGEFAFVLYSTAAASGVIAASQNA
NLTAIVVLSMALTPLVVLAVRPWLKHKEEKIDDLDVAEGLSGSVLMIGFGRFGQVVSQSL
LARGVDVTIIDTDVEMIRSAGTFGFKIYYGDGTRLDVLRASGADKAQVIAVCVDKKDAAN
RIVELAKAEFSQAKLLVRSFDREHSLELINAGVDVQVRETFESAIRFGHHALCQLGVPKD
EALEIVDEVRRRDAERVQLELAEGVMAGTRLMIGNVAPGPTPTPFTRPRTAATPLTAETA
EATQGSRE