Protein Info for ABIE51_RS06365 in Lysobacter sp. OAE881

Annotation: subclass B3 metallo-beta-lactamase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 291 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details PF00753: Lactamase_B" amino acids 60 to 194 (135 residues), 65.9 bits, see alignment E=2.4e-22

Best Hits

Swiss-Prot: 62% identical to BLA1_STEMA: Metallo-beta-lactamase L1 type 3 from Stenotrophomonas maltophilia

KEGG orthology group: None (inferred from 62% identity to sml:Smlt2667)

Predicted SEED Role

"FIG01112367: hypothetical protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (291 amino acids)

>ABIE51_RS06365 subclass B3 metallo-beta-lactamase (Lysobacter sp. OAE881)
MRLHAALCVSLTALSALPLHAAEPLLPQAQAYESSDAWRQPIAPFALADRSWYIGTAGLS
AVLVKTDAGAVLIDGGLPQAADMLLAHMRTLGVAPSDLKLILHSHAHIDHAGPIAAIKRA
TGARVVTNAESAVLLERGGFDDLHFGDGMVFPPAHADRIVMDGEVVELGGVAFTAHFTPG
HTPGSLSWTWTDAKAGKPLRIAYVDSLSAPGYKLVGNPRQPRIVDDYRRAFAEVRTLPCD
LLLTPHPDASGWKLGESTTPTTLTCRAYADRAERAFDKTLKEQQAASRGTR