Protein Info for ABIE51_RS06295 in Lysobacter sp. OAE881

Annotation: urocanate hydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 554 TIGR01228: urocanate hydratase" amino acids 10 to 553 (544 residues), 984.4 bits, see alignment E=7.3e-301 PF17391: Urocanase_N" amino acids 11 to 137 (127 residues), 201.9 bits, see alignment E=4.1e-64 PF01175: Urocanase" amino acids 140 to 348 (209 residues), 301.2 bits, see alignment E=6.1e-94 PF17392: Urocanase_C" amino acids 351 to 545 (195 residues), 310.8 bits, see alignment E=5e-97

Best Hits

Swiss-Prot: 83% identical to HUTU_PSEA7: Urocanate hydratase (hutU) from Pseudomonas aeruginosa (strain PA7)

KEGG orthology group: K01712, urocanate hydratase [EC: 4.2.1.49] (inferred from 86% identity to psu:Psesu_1929)

MetaCyc: 82% identical to urocanase subunit (Pseudomonas putida)
Urocanate hydratase. [EC: 4.2.1.49]

Predicted SEED Role

"Urocanate hydratase (EC 4.2.1.49)" in subsystem Histidine Degradation (EC 4.2.1.49)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.49

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (554 amino acids)

>ABIE51_RS06295 urocanate hydratase (Lysobacter sp. OAE881)
MSTRKDPSRVIRAPRGAEKSCKSWLTEAAYRMIQNNLDAEVAESPTELVVYGGIGRAARD
WESFDAILKSLRELDDNETLLVQSGKPVGIFPTHADAPRVLLANSNLVPHWATWEHFNEL
DRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFVEMGRQHYGGNLTGKWILTAGLGGMGGA
QPLAASLAGACSLNIECQQSRIDMRLRTRYVDEQATDLDDALARIEKYTQAGEAKSIALL
GNAAEILPELVRRGVRPDAVTDQTSAHDPVHGYLPIGWTVEQWQRMQSEDPARVRDAAKK
SMRVHVEAMLAFEDMGIPVFDYGNNIRQMAKDEGCQNAFDFPGFVPAYVRPLFCRGVGPF
RWVALSGDPEDIYKTDAKVKELIPDDAHLHRWLDMARERISFQGLPARICWVGLGLRHKL
GLAFNEMVRNGELKAPVVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNAMLNVAG
GATWVSLHHGGGVGMGYSQHSGVVIVCDGSEEADKRIARVLWNDPGTGVMRHADAGYDIA
KQCAREQGLKLPMA