Protein Info for ABIE51_RS04645 in Lysobacter sp. OAE881

Annotation: 3,4-dihydroxy-2-butanone-4-phosphate synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00506: 3,4-dihydroxy-2-butanone-4-phosphate synthase
  • amino acids 3 to 199 (197 residues), 235.3 bits, E=2.4e-74
• PF00926: DHBP_synthase
  • amino acids 8 to 198 (191 residues), 287.9 bits, E=3.1e-90
• PF00925: GTP_cyclohydro2
  • amino acids 208 to 366 (159 residues), 119.3 bits, E=1.2e-38

Best Hits

KEGG orthology group: K14652, 3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II [EC: 3.5.4.25 4.1.99.12] (inferred from 76% identity to xac:XAC0749)

Predicted SEED Role

"3,4-dihydroxy-2-butanone 4-phosphate synthase (EC 4.1.99.12) / GTP cyclohydrolase II (EC 3.5.4.25)" in subsystem Molybdenum cofactor biosynthesis or Riboflavin, FMN and FAD metabolism (EC 3.5.4.25, EC 4.1.99.12)

MetaCyc Pathways

• flavin biosynthesis I (bacteria and plants) (8/9 steps found)
• flavin biosynthesis III (fungi) (7/9 steps found)
• 6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia) (3/5 steps found)
• toxoflavin biosynthesis (3/7 steps found)
• flavin biosynthesis II (archaea) (5/10 steps found)

KEGG Metabolic Maps

• Riboflavin metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.4.25 or 4.1.99.12

Protein Sequence (370 amino acids)

>ABIE51_RS04645 3,4-dihydroxy-2-butanone-4-phosphate synthase (Lysobacter sp. OAE881)
MPFSPIPELLEEIRNGRMVVIVDDEDRENEGDLIMAAELVRPQDINFMVTHARGLVCLSL
TRERCRQLGLPPMVRDNTSPHHTNFTVSIEAAEGVTTGISAYDRAHTVRTAVRPDASASD
LSQPGHIFPLQAQPGGVLNRAGHTEAASDLALLAGLEPAGVLVEILNPDGSMARRPELEA
FAAEHGLKIGSIEELIRYRLETEHTIERVDAREIETEHGPFELFTYRDRLSHALHFALRR
GEPDVATPTLVRVHVQNPLADALHWRRPDFGPAVGDVLKAIAAEGRGALVLLADHADADA
LLARIRAPQHADEAGAGRGHALAEWRRNGAGGQILADLGLGKLRVLGTPRKQIGLAGFGL
EVVEYVEISH