Protein Info for ABIE51_RS04630 in Lysobacter sp. OAE881

Annotation: bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 364 transmembrane" amino acids 302 to 315 (14 residues), see Phobius details PF00383: dCMP_cyt_deam_1" amino acids 6 to 103 (98 residues), 67.4 bits, see alignment E=1.3e-22 PF14437: MafB19-deam" amino acids 8 to 111 (104 residues), 39.5 bits, see alignment E=7.2e-14 TIGR00326: riboflavin biosynthesis protein RibD" amino acids 11 to 356 (346 residues), 361.1 bits, see alignment E=6.1e-112 TIGR00227: riboflavin-specific deaminase C-terminal domain" amino acids 150 to 358 (209 residues), 162.5 bits, see alignment E=1e-51 PF01872: RibD_C" amino acids 151 to 354 (204 residues), 150.5 bits, see alignment E=8.1e-48

Best Hits

KEGG orthology group: K11752, diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC: 1.1.1.193 3.5.4.26] (inferred from 71% identity to psu:Psesu_0620)

Predicted SEED Role

"Diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26) / 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193)" in subsystem Riboflavin, FMN and FAD metabolism (EC 1.1.1.193, EC 3.5.4.26)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.193 or 3.5.4.26

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (364 amino acids)

>ABIE51_RS04630 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD (Lysobacter sp. OAE881)
MAFTATDHAMMARALRLAKRGAYTTKPNPMVGSVIAHGEEIVGEGWHERAGEPHAEVHAL
RAAGERAKGATAYVTLEPCAHTGRTGPCADALIAAGVSRVIAAMRDPFPQVDGAGFDKLR
AAGIEVASGLMEAQARALNRGFLSRVERGRPWLRVKLATSLDGRSALANGESKWISGEAS
RLDVQHWRARSGAIVTGAGTVLADDPALTVRMGDDTPFVPPLRVVLDPGLATVARGRVRE
GDAPTLYLHAPDAKPPRGLLAQHAAVPLRDGRFDLHAVLALLAGRGVNEIQLEAGATLAG
AFLGAGLVDEVLLYVAPVLLGERARPMFDGLAIDTMTQKLKMAIVESRYIGQDIRLLLRP
ESTV