Protein Info for ABIE51_RS04100 in Lysobacter sp. OAE881

Annotation: Na+/H+ antiporter NhaA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 406 transmembrane" amino acids 21 to 41 (21 residues), see Phobius details amino acids 69 to 89 (21 residues), see Phobius details amino acids 103 to 124 (22 residues), see Phobius details amino acids 136 to 155 (20 residues), see Phobius details amino acids 164 to 185 (22 residues), see Phobius details amino acids 191 to 207 (17 residues), see Phobius details amino acids 219 to 243 (25 residues), see Phobius details amino acids 275 to 293 (19 residues), see Phobius details amino acids 305 to 331 (27 residues), see Phobius details amino acids 344 to 367 (24 residues), see Phobius details amino acids 373 to 395 (23 residues), see Phobius details PF06965: Na_H_antiport_1" amino acids 17 to 395 (379 residues), 467.8 bits, see alignment E=1.2e-144 TIGR00773: Na+/H+ antiporter NhaA" amino acids 18 to 395 (378 residues), 433.1 bits, see alignment E=4.3e-134

Best Hits

Swiss-Prot: 55% identical to NHAA_RHORT: Na(+)/H(+) antiporter NhaA (nhaA) from Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 / S1)

KEGG orthology group: K03313, Na+:H+ antiporter, NhaA family (inferred from 55% identity to rru:Rru_A0128)

Predicted SEED Role

"Na+/H+ antiporter NhaA type" in subsystem Na(+) H(+) antiporter

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (406 amino acids)

>ABIE51_RS04100 Na+/H+ antiporter NhaA (Lysobacter sp. OAE881)
MHATNRPSPRALRGLAEFFRLEAAGGIVLIAAAVLAMVAANSPLVSYYEGFRALPVQVRV
GAFEIAKPLLLWINDGLMAVFFLLVALEIKREALSGQLATRAQLVLPMVCAAAGVAVPAL
LFVALNHSDAQAMRGWAVPTATDIAFALGVLALLGSRVPAGMKLLLSTIAVVDDLIAVLI
IAFFYSHGLSVTALVWAAVAVAGMWLLNRRGVMRLAPYLLLGVVLWVCVLKSGVHATLAG
VVTGLMIPHGRGTEDPADTHVHSPLESLEHALHPWVAYAILPVFAFANAGRVLGGMRLDD
LLAPLPMGVVLGLVVGKPIGIVGAAVLMRALGWARFPDGMDLRAMIGLGLMCGIGFTMSL
FIASLAYHDTDAYGSAVLGVLMASLLSAVGGWLWLRATLPRTTRMD