Protein Info for ABIE51_RS00370 in Lysobacter sp. OAE881

Annotation: UvrD-helicase domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 659 PF00580: UvrD-helicase" amino acids 4 to 265 (262 residues), 284.7 bits, see alignment E=2.3e-88 PF13245: AAA_19" amino acids 8 to 248 (241 residues), 86.3 bits, see alignment E=5.2e-28 PF13361: UvrD_C" amino acids 270 to 603 (334 residues), 212.8 bits, see alignment E=2.4e-66 PF13538: UvrD_C_2" amino acids 542 to 599 (58 residues), 43.2 bits, see alignment 7e-15

Best Hits

KEGG orthology group: K03656, ATP-dependent DNA helicase Rep [EC: 3.6.4.12] (inferred from 77% identity to xal:XALc_3164)

Predicted SEED Role

"ATP-dependent DNA helicase Rep" in subsystem DNA repair, bacterial UvrD and related helicases

Isozymes

Compare fitness of predicted isozymes for: 3.6.4.12

Use Curated BLAST to search for 3.6.4.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (659 amino acids)

>ABIE51_RS00370 UvrD-helicase domain-containing protein (Lysobacter sp. OAE881)
MHGLNPPQRAAVLHTDGPLLVLAGAGSGKTRVIVEKIAHLIASRAMPAKRIAAITFTNKS
AKEMKERVAKRIKGDAAEGLTVCTFHALGLKFLQIDHAKAGLRRGFSVFDSDDSTAQIKD
LMPPGSKPDAIDDMRNLISRAKNAGLSPEEALAVSKSPREMEAALMYQRYQARLSTFNAV
DFDDLIRLPVQMLEGDETLRLAWRERIGYLLVDECQDTNDAQYRLLKALAGEKGLFTCVG
DDDQSIYAWRGANPDNLLQLGKDYPSLQIIKLEQNYRCSNRVLRAANALIAHNPHEHPKT
LWSDQPDGERIRVWECRDSAHEAEKVAAEIHFLAAAKQAPWSDFCILFRGNFQSRVLEKS
LQLLRVPYHLSGGTAFLERGEVKDALSWLRLIANPDDDAAFLRAVQSPKREVGATTLARL
AELAQQAHMPMSRAAEQIGVLKQLQPRAANALDGFVSIVRHLRGEAFKISPAELVRMLAE
KSGLLASIRAQCKDEASFQRRKENLEELSEWFDGGKGSGPGELAAQLALLSHADKGEAGN
QVRMMSLHAAKGLEFRYVFIVGMEDGTLPHEMALEEGSLEEERRLLYVGITRAKEQLWLS
HSREASKWGDKLRLKPSRFFDELPAAEIQRDGADPVADAARKQERAAAGFAAIKALLGE