Protein Info for ABCV34_RS13810 in Castellaniella sp019104865 MT123

Annotation: aldo/keto reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 54% identical to DKGA_ECOLI: 2,5-diketo-D-gluconic acid reductase A (dkgA) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 63% identity to put:PT7_2609)

MetaCyc: 54% identical to methylglyoxal reductase DkgA (Escherichia coli K-12 substr. MG1655)
RXN0-7020 [EC: 1.1.1.346]; Aldehyde reductase. [EC: 1.1.1.346, 1.1.1.21]; 1.1.1.- [EC: 1.1.1.346, 1.1.1.21]; 1.1.1.- [EC: 1.1.1.346, 1.1.1.21]

Predicted SEED Role

No annotation

MetaCyc Pathways

methylglyoxal degradation III (1/2 steps found)
superpathway of methylglyoxal degradation (5/8 steps found)
L-ascorbate biosynthesis VIII (engineered pathway) (2/7 steps found)
ketogluconate metabolism (2/8 steps found)
detoxification of reactive carbonyls in chloroplasts (1/10 steps found)
superpathway of pentose and pentitol degradation (8/42 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.21 or 1.1.1.346

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (280 amino acids)

>ABCV34_RS13810 aldo/keto reductase (Castellaniella sp019104865 MT123)
MSSNQPYVTLHDGRRAPQLGLGTWKLTGDDVAPAIQAAVEAGYRAIDTAYIYENEAQVGQ
GIAKCGVPRDGLFVTTKLWNNRHRLDSAKAALRESLDKLQLDYVDLYLIHWPIPKENHYL
EAWEALIQLRDEGLAKSIGVCNFQIDHLQRLLDDTGVLPVVNQIELHPYFQQAELRAYHA
DHDIQTEAWSPLGQGQQLQDPVILELAHQLQASPAQIILRWHIQMGHMVIPKSSHPDRIR
ENFNLWNLFLDEAAMARIASLDRPDSRIGPDPDRFHLMKG