Protein Info for ABCV34_RS13540 in Castellaniella sp019104865 MT123
Annotation: adenosylhomocysteinase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 83% identical to SAHH_BORBR: Adenosylhomocysteinase (ahcY) from Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)
KEGG orthology group: K01251, adenosylhomocysteinase [EC: 3.3.1.1] (inferred from 85% identity to put:PT7_2551)Predicted SEED Role
"Adenosylhomocysteinase (EC 3.3.1.1)" in subsystem Methionine Biosynthesis or Methionine Degradation (EC 3.3.1.1)
MetaCyc Pathways
- S-adenosyl-L-methionine salvage II (3/3 steps found)
- L-methionine degradation I (to L-homocysteine) (2/3 steps found)
- superpathway of L-cysteine biosynthesis (mammalian) (2/5 steps found)
- superpathway of L-methionine salvage and degradation (5/16 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 3.3.1.1
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (468 amino acids)
>ABCV34_RS13540 adenosylhomocysteinase (Castellaniella sp019104865 MT123) MSTAHDYVIADIALADWGRREISIAETEMPGLMATREEFAASQPLKGARIAGSLHMTIQT AVLIETLKALGAEVRWASCNIFSTQDHAAAAIAAGGTPVFAVKGESLEDYWQYTHRIFDW QGEQANMILDDGGDATLLLHLGSRAESDPSVIAKPDNEEERVLFAAIKAQLARDPKWYST RLARIRGVTEETTTGVHRLYQMSQRGDLKIPAINVNDSVTKSKFDNLYGCRESLVDGIKR ATDVMVAGKIAVVCGFGDVGKGCAQALAALRAQVWVTEVDPICALQASMEGYRVVDLNDP DVVEQADMFVTATGNYHVIDREHLYRMKDQAIVCNIGHFDSEINVASVEDLPWEEIKPQV DHIIFPDGKRIILLAKGRLVNLGCATGHPSFVMSASFTNQTIAQIELFTRGEQYKTGQVY VLPKHLDEKVARLHLKKLGVRLTTLSDKQADYIGVPVNGPFKPGHYRY