Protein Info for ABCV34_RS12640 in Castellaniella sp019104865 MT123

Annotation: large conductance mechanosensitive channel protein MscL

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 transmembrane" amino acids 20 to 38 (19 residues), see Phobius details amino acids 90 to 112 (23 residues), see Phobius details TIGR00220: large conductance mechanosensitive channel protein" amino acids 7 to 149 (143 residues), 102.9 bits, see alignment E=7.3e-34 PF01741: MscL" amino acids 7 to 149 (143 residues), 137 bits, see alignment E=2.2e-44

Best Hits

Swiss-Prot: 65% identical to MSCL_BORPD: Large-conductance mechanosensitive channel (mscL) from Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)

KEGG orthology group: K03282, large conductance mechanosensitive channel (inferred from 65% identity to bpt:Bpet0123)

Predicted SEED Role

"Large-conductance mechanosensitive channel" in subsystem Potassium homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (150 amino acids)

>ABCV34_RS12640 large conductance mechanosensitive channel protein MscL (Castellaniella sp019104865 MT123)
MASARGFIKEFQEFAVKGNMMDLAIGVIIGGAFGKIIDSIVNDLVMPIINFIVGGKVNFD
NLFWVMRLPENYAGPMTAADLTKAGAVVFSWGHFLTVFVNFILLALVVFILVKMVNNARR
RFEAPPAPAAAPATPEDVLLLREIRDSLKR