Protein Info for ABCV34_RS11230 in Castellaniella sp019104865 MT123

Annotation: histidinol dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 435 PF00815: Histidinol_dh" amino acids 27 to 431 (405 residues), 553.2 bits, see alignment E=2e-170 TIGR00069: histidinol dehydrogenase" amino acids 36 to 430 (395 residues), 523.1 bits, see alignment E=2.8e-161

Best Hits

Swiss-Prot: 77% identical to HISX_BORPE: Histidinol dehydrogenase (hisD) from Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)

KEGG orthology group: K00013, histidinol dehydrogenase [EC: 1.1.1.23] (inferred from 77% identity to put:PT7_3121)

Predicted SEED Role

"Histidinol dehydrogenase (EC 1.1.1.23)" in subsystem Histidine Biosynthesis (EC 1.1.1.23)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.23

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (435 amino acids)

>ABCV34_RS11230 histidinol dehydrogenase (Castellaniella sp019104865 MT123)
MPLINRLDTRSADFDSALTRLLAYDASQDESIESTVRDILHDVQTRGDAAVLDYTARFDR
VQAGSLTALEIPRSDCQAALAGLPADRRAALEAAAERVRRYHEHQRAQTWTYTEPDGTML
GQQITPLDRVGLYVPGGKAAYPSSVLMNAIPAKVAGVPELIMVTPTPGGTRNPMVLAAAA
LGGVDRIFAIGGAQAVGALAYGTQTLPAVDKIVGPGNAYVAAAKRRVFGTVGIDMIAGPS
EILIVADGSTPAEWLAVDLFSQAEHDELAQAILLCPDEAYLNAVRDAIERLLPQQPRADI
LRVSLANRGALIHTTGLEQACSLVNRIAPEHLELSVRDPQAILPLIRHAGAIFMGAYSSE
SLGDYCAGPNHVLPTARTARFSSPLGVYDFQKRSSLIQVSATGAQTLGRIAVTLATSEGL
HAHAASAALRLNDPA