Protein Info for ABCV34_RS11075 in Castellaniella sp019104865 MT123

Annotation: uroporphyrinogen decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01208: URO-D
  • amino acids 5 to 348 (344 residues), 436.3 bits, E=3.9e-135
• TIGR01464: uroporphyrinogen decarboxylase
  • amino acids 9 to 347 (339 residues), 408.3 bits, E=1.2e-126

Best Hits

Swiss-Prot: 79% identical to DCUP_BORPD: Uroporphyrinogen decarboxylase (hemE) from Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)

KEGG orthology group: K01599, uroporphyrinogen decarboxylase [EC: 4.1.1.37] (inferred from 79% identity to bpt:Bpet0346)

MetaCyc: 62% identical to uroporphyrinogen decarboxylase (Escherichia coli K-12 substr. MG1655)
Uroporphyrinogen decarboxylase. [EC: 4.1.1.37]

Predicted SEED Role

"Uroporphyrinogen III decarboxylase (EC 4.1.1.37)" in subsystem Experimental tye or Heme and Siroheme Biosynthesis (EC 4.1.1.37)

MetaCyc Pathways

• superpathway of heme b biosynthesis from glutamate (9/10 steps found)
• heme b biosynthesis I (aerobic) (4/4 steps found)
• superpathway of heme b biosynthesis from glycine (6/8 steps found)
• heme b biosynthesis II (oxygen-independent) (3/4 steps found)
• heme b biosynthesis V (aerobic) (3/4 steps found)
• superpathway of heme b biosynthesis from uroporphyrinogen-III (4/6 steps found)
• heme b biosynthesis IV (Gram-positive bacteria) (2/5 steps found)
• 3,8-divinyl-chlorophyllide a biosynthesis I (aerobic, light-dependent) (3/9 steps found)
• 3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent) (3/9 steps found)
• 3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic) (2/9 steps found)
• superpathway of bacteriochlorophyll a biosynthesis (4/26 steps found)

KEGG Metabolic Maps

• Porphyrin and chlorophyll metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.37

Protein Sequence (355 amino acids)

>ABCV34_RS11075 uroporphyrinogen decarboxylase (Castellaniella sp019104865 MT123)
MTQLKNDTFLRALLRQPVPYTPIWMMRQAGRYLPEYNQTRAQAGSFLGLAQNPEYACEVT
LQPLRRFALDAAILFSDILTVPDAMGLGLRFVTGEGPQFERPLRDESSIAALQVPDLDTL
RYVFDAVSLIRKELDGAVPLIGFSGSPWTLACYMVEGAGSSDYRRIKTLLYQRPDLLHRI
LDVNARAVQAYLNAQIQAGAQAVMVFDSWGGVLADGLFQQFSLHYTQRVIDGLLREHDGR
RVPVIVFTKGGGQWVEDIAAIGCDAVGLDWTARLGAARSRVGDRVALQGNLDPMALFGGD
AAIRAEARRVLADFGPVGAGGHVFNLGHGISQFTSPEAVVSLVDEVHTASRAYHA