Protein Info for ABCV34_RS10925 in Castellaniella sp019104865 MT123

Annotation: homoserine O-acetyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01392: homoserine O-acetyltransferase
  • amino acids 38 to 393 (356 residues), 459.7 bits, E=3.2e-142
• PF00561: Abhydrolase_1
  • amino acids 68 to 381 (314 residues), 81.5 bits, E=4.1e-27

Best Hits

Swiss-Prot: 76% identical to METXS_BORPA: Homoserine O-succinyltransferase (metXS) from Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)

KEGG orthology group: K00641, homoserine O-acetyltransferase [EC: 2.3.1.31] (inferred from 79% identity to put:PT7_2404)

Predicted SEED Role

"Homoserine O-acetyltransferase (EC 2.3.1.31)" in subsystem Methionine Biosynthesis (EC 2.3.1.31)

MetaCyc Pathways

• superpathway of L-methionine biosynthesis (by sulfhydrylation) (11/12 steps found)
• L-methionine biosynthesis III (4/4 steps found)
• L-homocysteine biosynthesis (2/2 steps found)
• superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) (6/10 steps found)
• superpathway of L-cysteine biosynthesis (fungi) (3/6 steps found)

KEGG Metabolic Maps

• Methionine metabolism
• Sulfur metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.3.1.31

Protein Sequence (414 amino acids)

>ABCV34_RS10925 homoserine O-acetyltransferase (Castellaniella sp019104865 MT123)
MTAIAISPDSAAAHADPAHPPVPTGSVGYVSPRFLSFDEPLTLSSGQVISSYTLAVETYG
TLNAQRSNAVLVCHALNASHHVAGMDAEHPDQIGWWDNMVGPGKAVDTDRFFVIGINNLG
SCFGSTGPTSINPDTGKPWGAAFPLLTVEDWVRAQARVADHFGIERLAAVMGGSLGGMQA
LSWAITCPERVGDCIVVASTARLTAQNIAFNEVARRAILTDPDFRDGDYYAHGVVPTHGL
SVARMVGHITYQSDEVMAAKFGRAQQAPGPDGDYHYNYDVEFEVESYLRHQGEKFSRYFD
ANTYLLLTRALDYFDPARAHGGDLAQALSPAQARFLLVSFSTDWRFAPEHSREIVRALLK
NQREVTYAEIDAPHGHDAFLLGDVRYHAIVQGYYDQIARRLDLGERSRTTGVLA