Protein Info for ABCV34_RS09900 in Castellaniella sp019104865 MT123

Annotation: leucine efflux protein LeuE

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 212 transmembrane" amino acids 12 to 34 (23 residues), see Phobius details amino acids 45 to 67 (23 residues), see Phobius details amino acids 74 to 96 (23 residues), see Phobius details amino acids 121 to 142 (22 residues), see Phobius details amino acids 154 to 177 (24 residues), see Phobius details amino acids 189 to 207 (19 residues), see Phobius details PF01810: LysE" amino acids 18 to 210 (193 residues), 144 bits, see alignment E=2.1e-46

Best Hits

Swiss-Prot: 53% identical to LEUE_SALTI: Leucine efflux protein (leuE) from Salmonella typhi

KEGG orthology group: K11250, leucine efflux protein (inferred from 58% identity to bps:BPSL1350)

Predicted SEED Role

"L-lysine permease" in subsystem Lysine degradation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (212 amino acids)

>ABCV34_RS09900 leucine efflux protein LeuE (Castellaniella sp019104865 MT123)
MLAHYGVVDIWTYLAGTIFIILLPGPNSLFVLATGAGRGVRAGYQAACGVFLGDSILMTL
TAAGAASVLRLLPVLFFVLKAAGAVYLGYLGIRLLLSAWRPAHGAARTVHGAAAGNPFHK
ALLLSLLNPKAILFLLSFFVQFVDPAYSHPAIPFLILAAILQACSVLYLSVLIFGGARLA
AAFRRRQGLARVGSGLVGILFLWFAGRMAVEA