Protein Info for ABCV34_RS09655 in Castellaniella sp019104865 MT123

Annotation: putative lipid II flippase FtsW

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 397 transmembrane" amino acids 26 to 50 (25 residues), see Phobius details amino acids 62 to 83 (22 residues), see Phobius details amino acids 93 to 114 (22 residues), see Phobius details amino acids 159 to 178 (20 residues), see Phobius details amino acids 183 to 202 (20 residues), see Phobius details amino acids 208 to 226 (19 residues), see Phobius details amino acids 286 to 311 (26 residues), see Phobius details amino acids 331 to 354 (24 residues), see Phobius details amino acids 366 to 386 (21 residues), see Phobius details TIGR02614: cell division protein FtsW" amino acids 27 to 387 (361 residues), 404.9 bits, see alignment E=1.6e-125 PF01098: FTSW_RODA_SPOVE" amino acids 29 to 389 (361 residues), 345.5 bits, see alignment E=1.7e-107

Best Hits

Swiss-Prot: 60% identical to FTSW_BURTA: Probable peptidoglycan glycosyltransferase FtsW (ftsW) from Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 / E264)

KEGG orthology group: K03588, cell division protein FtsW (inferred from 78% identity to put:PT7_0011)

MetaCyc: 42% identical to peptidoglycan glycosyltransferase FtsW (Escherichia coli K-12 substr. MG1655)
Peptidoglycan glycosyltransferase. [EC: 2.4.1.129]

Predicted SEED Role

"Cell division protein FtsW" in subsystem Bacterial Cell Division or Bacterial Cytoskeleton

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.4.1.129

Use Curated BLAST to search for 2.4.1.129

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (397 amino acids)

>ABCV34_RS09655 putative lipid II flippase FtsW (Castellaniella sp019104865 MT123)
MSMLGELSASLNAVRPGRTTMPSVDVSVIVAVAALLLFGLLMVYSASIALADGPRYESYG
RFYFVGRHAVFIVVGLFAALFTASVPMRVWQKLALPMFALALLLLLVVVVPGIGREVNGA
RRWLPLGPLNFQPSELMKVAVTLYAADYVVRKQAHLQGFWRGFVPMALALVMVGLLLLME
PDLGAFIVIGAIAVGVLFIGGINLKLFSTLLAGVMSCFLLLIWLSPWRRERLFVYLDPWN
PDNAYGSAYQLSHSLIALGRGEWFGVGLGASIEKLHYLPEAHTDFIVAVIGEELGFVGVL
CLIAVFVYLVLRGFEIARQAMVLERVFDGLVAQGVALWMGVQTFINVGVCVGLLPTKGLT
LPLVSYGGSGIVLNLVAIALLLRVDYETRCMMRGKRR