Protein Info for ABCV34_RS09065 in Castellaniella sp019104865 MT123

Annotation: molecular chaperone HtpG

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 633 PF02518: HATPase_c" amino acids 34 to 187 (154 residues), 28 bits, see alignment E=3.8e-10 PF13589: HATPase_c_3" amino acids 34 to 150 (117 residues), 32.6 bits, see alignment E=1.1e-11 PF00183: HSP90" amino acids 221 to 631 (411 residues), 426.2 bits, see alignment E=3.6e-131

Best Hits

Swiss-Prot: 80% identical to HTPG_BORPE: Chaperone protein HtpG (htpG) from Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)

KEGG orthology group: K04079, molecular chaperone HtpG (inferred from 79% identity to put:PT7_2182)

MetaCyc: 60% identical to chaperone protein HtpG (Escherichia coli K-12 substr. MG1655)
Non-chaperonin molecular chaperone ATPase. [EC: 3.6.4.10, 5.6.1.7]

Predicted SEED Role

"Chaperone protein HtpG" in subsystem Protein chaperones

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.4.10 or 5.6.1.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (633 amino acids)

>ABCV34_RS09065 molecular chaperone HtpG (Castellaniella sp019104865 MT123)
MSQTDTQTAETLGFQAEVKQLLHLMIHSLYSNKEIFLRELVSNASDACDKLRFEAIDHPE
WLEGDGELHIRVEFDKAARTITITDNGIGLSRDEAIANLGTIARSGTREFFSQLTGDKQK
DAQLIGQFGVGFYSSFIVADKVSVRSRRADLPAAEGVLWESDGQGEFSVSAIEQAARGTS
VTLTLRADEDDFLSGWKLREVLRRYSDHISLPIQMKKEEWDAEKSEQVTRDEWETVNQAN
ALWTRSKSDITDEQYQEFYKHIAHDPENPLAWTHNRVEGRSEYTQLLYVPKRAPFDLYDR
DARRGVKLYIKRVFIMDDAEQLLPTYLRFVRGVVDSADLPLNVSREILQESRDVRSIREG
CAKRILGLLEDLSKDKPEEYAEFWTQFGQVLKEGAGEDPANKDRIAGLMRFASTQSDSPA
QTVSLADYIGRMKEGQDKIYYLTADSYAAAAHSPHLEVFRRKGLEVLLLSDRVDEWMLSY
LREFEGKSLASVAKGGLDLDALADEAEKKQQAEVAEAFKPTIERLKAALDGRVKEVRATV
RLVDSPACVVVDENELSPHLMRMLKAAGQEAPEVKPILEVNPQHALVKRLEAQPDATFGD
WAELLLDQAMLAEGAALKDPASFVKRMNALLLA