Protein Info for ABCV34_RS08795 in Castellaniella sp019104865 MT123

Annotation: phosphoribosylformylglycinamidine cyclo-ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00878: phosphoribosylformylglycinamidine cyclo-ligase
  • amino acids 9 to 338 (330 residues), 441.5 bits, E=1e-136
• PF00586: AIRS
  • amino acids 61 to 166 (106 residues), 82.8 bits, E=2.4e-27
• PF02769: AIRS_C
  • amino acids 178 to 340 (163 residues), 125.7 bits, E=1.8e-40

Best Hits

Swiss-Prot: 84% identical to PUR5_BORPD: Phosphoribosylformylglycinamidine cyclo-ligase (purM) from Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)

KEGG orthology group: K01933, phosphoribosylformylglycinamidine cyclo-ligase [EC: 6.3.3.1] (inferred from 84% identity to bpt:Bpet0825)

Predicted SEED Role

"Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)" in subsystem De Novo Purine Biosynthesis (EC 6.3.3.1)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (43/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (23/26 steps found)
• 5-aminoimidazole ribonucleotide biosynthesis I (5/5 steps found)
• superpathway of 5-aminoimidazole ribonucleotide biosynthesis (5/6 steps found)
• 5-aminoimidazole ribonucleotide biosynthesis II (4/5 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.3.1

Protein Sequence (349 amino acids)

>ABCV34_RS08795 phosphoribosylformylglycinamidine cyclo-ligase (Castellaniella sp019104865 MT123)
MTQGTTPSMTYRDAGVDIDAGDALVDRIKPLAARTMRPGVMAGIGGFGALFQVPPHLREP
VLVSGTDGVGTKLRLAFEWQRHDTVGIDLVAMSVNDILVQGAEPLYFLDYFACGKLSVDT
AARVVGGIARGCELAGCALIGGETAEMPGMYPDGEYDLAGFAVGAVEKSAIIDGADIRVG
DTVLGLASSGAHSNGYSLVRKILQHAGARPDQDLGGRPLGDVVMEPTRIYVKSVLAALAA
HGRAIKGLAHITGGGLLENVPRILKSGLCAHLHRDAWQWPLLFQWLQTQGGVSDHEMARV
FNCGIGMVLVVDPAQADAVAATLRAQGETVHTLGRIQDQTAGGPQTIVD