Protein Info for ABCV34_RS05240 in Castellaniella sp019104865 MT123

Annotation: signal peptidase II

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 175 transmembrane" amino acids 20 to 40 (21 residues), see Phobius details amino acids 52 to 72 (21 residues), see Phobius details amino acids 78 to 98 (21 residues), see Phobius details amino acids 105 to 122 (18 residues), see Phobius details amino acids 142 to 162 (21 residues), see Phobius details TIGR00077: signal peptidase II" amino acids 25 to 171 (147 residues), 132.1 bits, see alignment E=8.8e-43 PF01252: Peptidase_A8" amino acids 26 to 165 (140 residues), 145 bits, see alignment E=9.2e-47

Best Hits

Swiss-Prot: 51% identical to LSPA_CUPNJ: Lipoprotein signal peptidase (lspA) from Cupriavidus necator (strain JMP 134 / LMG 1197)

KEGG orthology group: K03101, signal peptidase II [EC: 3.4.23.36] (inferred from 64% identity to put:PT7_0715)

MetaCyc: 42% identical to lipoprotein signal peptidase (Escherichia coli K-12 substr. MG1655)
Signal peptidase II. [EC: 3.4.23.36]

Predicted SEED Role

"Lipoprotein signal peptidase (EC 3.4.23.36)" in subsystem Sex pheromones in Enterococcus faecalis and other Firmicutes or Signal peptidase (EC 3.4.23.36)

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.23.36

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (175 amino acids)

>ABCV34_RS05240 signal peptidase II (Castellaniella sp019104865 MT123)
MKGTQASTDATPSRRWRALGGWLLWAALLIVLDQGTKAWISQSLTYAERIHILPVFDLTL
LFNTGAAFSFLAEGGGAQRWLFTGIALIAAALILRWLYTHAGQRLLCAALASILGGALGN
ALDRLMHGHVVDFLLFYWRDWYFPAFNVADVAITCGAGLLILDEILRARRARKTG