Protein Info for ABCV34_RS04590 in Castellaniella sp019104865 MT123

Annotation: CDP-glucose 4,6-dehydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 376 TIGR02622: CDP-glucose 4,6-dehydratase" amino acids 28 to 369 (342 residues), 459.3 bits, see alignment E=4.3e-142 PF04321: RmlD_sub_bind" amino acids 33 to 195 (163 residues), 37.2 bits, see alignment E=4.7e-13 PF02719: Polysacc_synt_2" amino acids 34 to 247 (214 residues), 46.6 bits, see alignment E=6.9e-16 PF01370: Epimerase" amino acids 34 to 270 (237 residues), 108.1 bits, see alignment E=1.2e-34 PF16363: GDP_Man_Dehyd" amino acids 35 to 315 (281 residues), 115.5 bits, see alignment E=9.4e-37 PF07993: NAD_binding_4" amino acids 102 to 214 (113 residues), 23 bits, see alignment E=1e-08

Best Hits

Swiss-Prot: 45% identical to RFBG_SALTY: CDP-glucose 4,6-dehydratase (rfbG) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K01709, CDP-glucose 4,6-dehydratase [EC: 4.2.1.45] (inferred from 71% identity to avn:Avin_27770)

MetaCyc: 47% identical to CDP-D-glucose-4,6-dehydratase monomer (Yersinia pseudotuberculosis)
CDP-glucose 4,6-dehydratase. [EC: 4.2.1.45]

Predicted SEED Role

"Similar to CDP-glucose 4,6-dehydratase (EC 4.2.1.45)" (EC 4.2.1.45)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.45

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (376 amino acids)

>ABCV34_RS04590 CDP-glucose 4,6-dehydratase (Castellaniella sp019104865 MT123)
MGVGSGAVEDLGVMQVGKPALVDPDPAFWRGRRVLLTGHTGFKGSWLALWLHRLGAQVTG
IALPPSKERNLYSLARVDDGCESHFIDIRDAHAVAGQIRQAKPEIVFHLAAQALVRAGYE
DPLATYATNVMGTAHVLDALRGLESVRAAVMVTTDKVYRNLEQAYPYREDDALGGHDPYS
ASKAASELVIASYRDAWLAAQGVAVASARAGNVIGGGDWAADRLIPDAARCWQAGRVVQI
RSPRATRPWQHVLEPIGAYLRLAEALQAQPALAGAYNFGPHTHEAATVRQVIERARHAYG
SGDIQWGDGTEGPHEAGWLALEIARARTVLGVQPRWGLQESIVRTMNWYRLQNEGADARA
LCEADIQAFEQAGAAP