Protein Info for ABCV34_RS03700 in Castellaniella sp019104865 MT123

Annotation: quinolinate synthase NadA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00550: quinolinate synthetase complex, A subunit
  • amino acids 41 to 351 (311 residues), 351.1 bits, E=2.6e-109
• PF02445: NadA
  • amino acids 44 to 350 (307 residues), 344.2 bits, E=2.8e-107

Best Hits

Swiss-Prot: 74% identical to NADA_RALPJ: Quinolinate synthase A (nadA) from Ralstonia pickettii (strain 12J)

KEGG orthology group: K03517, quinolinate synthase [EC: 2.5.1.72] (inferred from 74% identity to hse:Hsero_2216)

MetaCyc: 62% identical to quinolinate synthase (Escherichia coli K-12 substr. MG1655)
Quinolinate synthase. [EC: 2.5.1.72]

Predicted SEED Role

"Quinolinate synthetase (EC 2.5.1.72)" in subsystem NAD and NADP cofactor biosynthesis global or NAD regulation (EC 2.5.1.72)

MetaCyc Pathways

• aspartate superpathway (22/25 steps found)
• NAD de novo biosynthesis I (5/6 steps found)
• NAD de novo biosynthesis III (4/6 steps found)
• NAD de novo biosynthesis IV (anaerobic) (4/6 steps found)
• nicotine biosynthesis (3/9 steps found)
• superpathway of nicotine biosynthesis (4/12 steps found)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.5.1.72

Protein Sequence (378 amino acids)

>ABCV34_RS03700 quinolinate synthase NadA (Castellaniella sp019104865 MT123)
MPSGNRIVEFDRPDMASGTLSVAEAWARVNPPLSSEERDFQKTRVRSLLKLRNAVLVAHY
YVDADIQDLAEETGGCVSDSLEMARFGRDHAADTLVVSGVRFMGETAKILSPEKRILMPD
LDATCSLDLGCDPVAFAQFRAQHPDRVVVVYANTSAAVKAQADWMVTSSIGLDIVADLHN
QGKKILWAPDRHLGSYIQRQTGADMVLWQGSCTVHDEFKSIELDLMRRDHPDALILVHPE
SPAAVVSQADVVGSTSRLLAAVTESSATTFIVATDQGLLHKMRLAAPGKTFIAAPTAGES
ATCKSCAHCPWMAMNSLKGVADALEFGTNEIHLDPALGRQAKVCIDRMLDFAAARKRKVQ
PGPDLAQEQALFSQVGPA