Protein Info for ABCV34_RS03235 in Castellaniella sp019104865 MT123

Annotation: Cu(+)/Ag(+) sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 465 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details amino acids 171 to 192 (22 residues), see Phobius details PF21085: CusS" amino acids 4 to 164 (161 residues), 176.6 bits, see alignment E=1e-55 TIGR01386: heavy metal sensor kinase" amino acids 5 to 464 (460 residues), 482.3 bits, see alignment E=8.4e-149 PF00672: HAMP" amino acids 195 to 241 (47 residues), 34.3 bits, see alignment 6e-12 PF00512: HisKA" amino acids 247 to 311 (65 residues), 49 bits, see alignment E=1.3e-16 PF02518: HATPase_c" amino acids 356 to 454 (99 residues), 89.4 bits, see alignment E=5.4e-29 PF14501: HATPase_c_5" amino acids 362 to 464 (103 residues), 31 bits, see alignment E=5e-11

Best Hits

KEGG orthology group: K07644, two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC: 2.7.13.3] (inferred from 70% identity to net:Neut_0017)

Predicted SEED Role

"Osmosensitive K+ channel histidine kinase KdpD (EC 2.7.3.-)" in subsystem Potassium homeostasis (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (465 amino acids)

>ABCV34_RS03235 Cu(+)/Ag(+) sensor histidine kinase (Castellaniella sp019104865 MT123)
MTHRPASLALRLTLSIGAVITVVLLTFGWVVERSISDHFAQQDVDELNAVVQALQQSLSA
SPIDEAPAALRRRLAAAVSGHHDAEYRISDASGAVIYATPGSALDRFSRLPPSGNKVDIG
SVRIWQDDGRTYRGAVVRLVPHAASANTPWTVTVATGIDFHLRYFRSFRDYLRLITLAAA
LIAILAIWFAVYQGHAPIRRISREMRRIKSDQLYIRLAPEAVPAELTELAISFNDMLDRI
ESVFRRLSNFSADIAHEMRTPITNLMTQTEVALSQVRSVEQYREVLYSNLEEYERMAKMV
SDMLFLAQADNKLLKPEMVAVDLADEVRGLFDYFEAWAEERAVALILAGPDVCVQGDRLM
IRRALSNLLSNAIRHTPKGAAVRVSISATDDTGVLRVQNPASAISPEHLPHLFDRFYRPD
SSRQRGEDGAGLGLAIVKSIVEAHGGSVSASSSENLITFEMILPT