Protein Info for ABCV34_RS00960 in Castellaniella sp019104865 MT123

Annotation: EAL domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 725 TIGR00229: PAS domain S-box protein" amino acids 43 to 86 (44 residues), 30.7 bits, see alignment 2.9e-11 amino acids 157 to 271 (115 residues), 38.7 bits, see alignment E=1e-13 PF00989: PAS" amino acids 43 to 83 (41 residues), 30.3 bits, see alignment 1.1e-10 amino acids 158 to 258 (101 residues), 36.1 bits, see alignment E=1.8e-12 PF08448: PAS_4" amino acids 43 to 93 (51 residues), 25.7 bits, see alignment 3.4e-09 amino acids 160 to 265 (106 residues), 33.3 bits, see alignment E=1.5e-11 PF13426: PAS_9" amino acids 45 to 92 (48 residues), 26.6 bits, see alignment 1.8e-09 amino acids 163 to 264 (102 residues), 36.2 bits, see alignment E=1.8e-12 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 275 to 437 (163 residues), 146.4 bits, see alignment E=6.4e-47 PF00990: GGDEF" amino acids 277 to 434 (158 residues), 176.1 bits, see alignment E=1.4e-55 PF00563: EAL" amino acids 454 to 691 (238 residues), 247 bits, see alignment E=5.2e-77

Best Hits

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (725 amino acids)

>ABCV34_RS00960 EAL domain-containing protein (Castellaniella sp019104865 MT123)
MFPPSAPIRPFHNQDSGPASVMPPVESSDRSHILALLRLGDFSQDAFFATDTQGAILYMN
RSAERLFGYRRGDAVGLRVDALLPDVAEVNARLDQEGARNALLWRGRGQHRQHMALNLAG
AATQICSQTGHSHLYIMRQHRGGLSDTDRQAELASLVYRSTSEGMLVLDPRGVILDVNPA
FVSLRGRAESDVVGRHVRCLNSPCHDREFYRVMWRTVMETGSWQGEHWGQHVNGELYPEW
LSINTSFNDQGEVHRRVMIFSNIAEIKQAEAIIWKQANFDRLTDLPNRQMFHDRLEQSIL
KARRTGGRIGLLFLDLDRFKEINDTLGHAMGDELLKEASRRLSACVRQSDTVARLGGDEF
TVLLDGVHEPRDVERLTRAILRSLAEPFRLGVETVFISTSIGITFYPDDATDAETLLNNA
DQAMYSAKAEGRNRSCYFTLSMQERAQKRMRLVNDLHLALDQNQFSLDFQPIVDLRSGRV
VKAETLLRWHHPVRGLVSPAEFIPLAEETGIIRPLGDWVFCEATRQISEWRNRFDRDIQV
SVNISPAQLRHEGLDLAFWSTHLNTLGLASRHVIIEITEGLLIDSGDDRIRLQLEAFRTA
GMQVALDDFGTGYSSLSYLRKFDIDFLKIDQSFVANLSRGSADHALCEAIILLAHKLGLS
VVAEGIETPRQYDLLAAAGCDFGQGYLFARPMAAHMFEGLLAVGADVRPAHARQGGAAEH
TASDR