Protein Info for ABCV34_RS00605 in Castellaniella sp019104865 MT123
Annotation: benzoate-CoA ligase family protein
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K04110, benzoate-CoA ligase [EC: 6.2.1.25] (inferred from 69% identity to axy:AXYL_05035)MetaCyc: 57% identical to benzoate-CoA ligase subunit (Aromatoleum evansii)
Anthranilate--CoA ligase. [EC: 6.2.1.32]; Benzoate--CoA ligase. [EC: 6.2.1.32, 6.2.1.25]
Predicted SEED Role
"Benzoate-CoA ligase (EC 6.2.1.25)" in subsystem Benzoate transport and degradation cluster (EC 6.2.1.25)
MetaCyc Pathways
- benzoate degradation II (aerobic and anaerobic) (1/1 steps found)
- anthranilate degradation II (aerobic) (1/2 steps found)
- anthranilate degradation III (anaerobic) (1/2 steps found)
- 4-hydroxy-2(1H)-quinolone biosynthesis (3/5 steps found)
- benzoate biosynthesis I (CoA-dependent, β-oxidative) (5/9 steps found)
- aurachin RE biosynthesis (1/5 steps found)
- superpathway of quinolone and alkylquinolone biosynthesis (3/10 steps found)
- 2-heptyl-3-hydroxy-4(1H)-quinolone biosynthesis (1/8 steps found)
- aurachin A, B, C and D biosynthesis (3/11 steps found)
- benzoate fermentation (to acetate and cyclohexane carboxylate) (5/17 steps found)
- anaerobic aromatic compound degradation (Thauera aromatica) (5/27 steps found)
KEGG Metabolic Maps
- Acridone alkaloid biosynthesis
- Benzoate degradation via CoA ligation
- Biosynthesis of alkaloids derived from shikimate pathway
- Carbazole degradation
Isozymes
No predicted isozymesUse Curated BLAST to search for 6.2.1.25 or 6.2.1.32
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (520 amino acids)
>ABCV34_RS00605 benzoate-CoA ligase family protein (Castellaniella sp019104865 MT123) MAPCPEQLNFARHLFDLNAGRATKTAYLDGQRSLSYGELEQRSIRFAGLLKQLGLHREER ILLLMHDTVDWPVCFLGSLLAGVVPIAANTLLTADDYAYILQNSRCQAAFVSQALLPVLQ RAMLKVSHEVAHIVVAQPELPLSEGMIDFEAALAQAPAPTPVDTQTDETAFWLYSSGSTG LPKAVVHTHGNLWYTAELYGKPILGVRESDTVFSAAKMFFAYGLGNALTFPLSVGATVLL LSGRPTADAVFEHLTRHRPTIFCGVPTLYASMLSSPQLPSKEQLTLRVCASAGEALPKDL GDRFTEHFGCYILDGIGSTEMLHIFLTNQPGDIHYGTTGKPVPGYEVELRDEAGNPTPVG QIGDLYIKGPSAALMYWHNRKKSHDTFLGEWLKSGDKYTVDAQGYYTYAGRSDDMIKVSG QYVSPAEVEGTLIRHPLVLEAAVIGAPDHEGLIKTIAYVVLRPGTTHSEAIELELKTFVK SNLAPHKYPRIIIFLDDLPKTATGKIQRFRLRQQHESVPA