Protein Info for DvMF_2963 in Desulfovibrio vulgaris Miyazaki F

Annotation: diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s) (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1251 transmembrane" amino acids 84 to 104 (21 residues), see Phobius details amino acids 115 to 137 (23 residues), see Phobius details TIGR00229: PAS domain S-box protein" amino acids 180 to 279 (100 residues), 33.9 bits, see alignment E=3e-12 amino acids 345 to 389 (45 residues), 30.4 bits, see alignment (E = 3.8e-11) amino acids 483 to 604 (122 residues), 47.1 bits, see alignment E=2.5e-16 PF13188: PAS_8" amino acids 345 to 388 (44 residues), 33.5 bits, see alignment (E = 1.3e-11) PF00989: PAS" amino acids 346 to 388 (43 residues), 32.6 bits, see alignment (E = 3.1e-11) amino acids 487 to 599 (113 residues), 30.3 bits, see alignment E=1.7e-10 PF08448: PAS_4" amino acids 354 to 475 (122 residues), 42.5 bits, see alignment E=3.1e-14 PF13426: PAS_9" amino acids 355 to 473 (119 residues), 23.5 bits, see alignment E=2.6e-08 PF08447: PAS_3" amino acids 509 to 595 (87 residues), 60.5 bits, see alignment 7e-20 PF13185: GAF_2" amino acids 622 to 761 (140 residues), 48.7 bits, see alignment E=4.3e-16 PF01590: GAF" amino acids 624 to 760 (137 residues), 47.4 bits, see alignment E=1.3e-15 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 769 to 934 (166 residues), 136 bits, see alignment E=1.1e-43 PF00990: GGDEF" amino acids 773 to 930 (158 residues), 162 bits, see alignment E=4.8e-51 PF00563: EAL" amino acids 952 to 1188 (237 residues), 259.9 bits, see alignment E=9.1e-81

Best Hits

KEGG orthology group: None (inferred from 100% identity to dvm:DvMF_2963)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8DSE5 at UniProt or InterPro

Protein Sequence (1251 amino acids)

>DvMF_2963 diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s) (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MTTRRKAPWPQEASSHAPSRVTADCPRRSRMTQPGLVPAARHHAADTPRRIRRLRTPPHP
RLVLHAFRLPVLPFVPRLRLPLPTLIDIGAVAAAAIVTPIATVRPAWAAVEGAVPWTSSA
LLFGLAAGLVLGLLAGLRLRRGKAAGAKQDVQRGALPHAHAAASGQADASTQAVDLDRAR
EQYHAIFTNAPVGIFRVTPEGRYENVNPEYARIWGCPTTEEMLECVSDIPRQMYANPADR
QRFVGALQATGRVDRMELRLKRRDGSLFWGLVSARLVRGPAPAQAAQTGQIAKTGQTAGT
GVTNGTYRADAKAGNAPAEVDYIDGFVLDITEQKAMQDQLSEAWRRLRDIIDFLPDAVLV
LDASRRVIAWNRAMEEMTGHSASEMLGRGNFAYALPFYGERIPLLGDWFFSPDMPQPSHY
TRFSEHGDKLAAEAYVPTLFGGRGAHVWTVASALRDGEGRLNGVIQTIRDITERHNQMRE
LEKSRQRYDMAISATNDGIWEWELDTNTLYHSPRCLEILGRAPDATLSPMAIAAILHPED
RLRVLTEVRRITGEDAERFEHEFRIRHTDGTWRWVLARGAARRGPGGRLNRVAGALADIT
DHKQGDAIAGILFHIANAINETRDLDELFLSIHTALRRHVQAPNFFIALINEPEDRLDFA
YFADERDARYNPVEHISDPAVQSPTLEVIRTGRQVHLHSDDIEARPVFGSRPAAWLGTPL
RSRGKVIGAMVVQHYEDSEFFSARDAELMVPVAEQVAVAIERKQGEEMLTHLALHDPLTG
LPNRALLLDRIERAIQRRRRNDSYRFAVLMLDLDRFKFINDSHGHTTGDNLLVEVARRMR
PVVRAGDTVARLGGDEFALLLEDVDSPRRIVQITRRLLAALERPVRMGAKVVRTSASIGM
VLRTQGYDTADALLRDADIAMYQAKAQGKGRFRVFNQSMHRHTMEMMTLEGDLSMAMRRK
QLYLEYQPVLAVDGARLLGFEALVRWRHPTEGAVPPARFIPMAEETGLILRIGQWVLEQA
AATLARWRATLPGAHDLYVSVNLSARQASQPNLTGRVARILSDTGLPPEALKLEITETAI
MKDPDGALQRLEALRRLGVGIGIDDFGTGYSSLAYLQRFPVDTLKVDRSFVSAVAGDAEN
REIVRTVVTLGRSLGLHVVAEGVETAEQFAIVAELGCHSVQGYHFSRPVAEERAVAFIAA
GGVPDASTGTTAPTGAGGPDGLRGPDEPDGPDGPGEPDGPDEPDASAPATT