Protein Info for DvMF_2895 in Desulfovibrio vulgaris Miyazaki F

Annotation: methyl-viologen-reducing hydrogenase delta subunit (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 754 PF07992: Pyr_redox_2" amino acids 147 to 265 (119 residues), 28.2 bits, see alignment E=7.6e-10 PF13450: NAD_binding_8" amino acids 150 to 184 (35 residues), 25.3 bits, see alignment (E = 9.3e-09) PF00037: Fer4" amino acids 543 to 562 (20 residues), 22.3 bits, see alignment (E = 5.5e-08) PF13187: Fer4_9" amino acids 546 to 592 (47 residues), 34.3 bits, see alignment 1.2e-11 PF12838: Fer4_7" amino acids 546 to 589 (44 residues), 28.6 bits, see alignment 9.8e-10 PF12800: Fer4_4" amino acids 546 to 560 (15 residues), 13.4 bits, see alignment (E = 5.1e-05) amino acids 574 to 589 (16 residues), 16.5 bits, see alignment (E = 5.4e-06) PF02662: FlpD" amino acids 622 to 744 (123 residues), 130.6 bits, see alignment E=2e-41

Best Hits

KEGG orthology group: K03388, heterodisulfide reductase subunit A [EC: 1.8.98.1] (inferred from 100% identity to dvm:DvMF_2895)

Predicted SEED Role

"heterodisulfide reductase, subunit A/methylviologen reducing hydrogenase, subunit delta" in subsystem Anaerobic respiratory reductases or Hydrogenases

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.8.98.1

Use Curated BLAST to search for 1.8.98.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8DS77 at UniProt or InterPro

Protein Sequence (754 amino acids)

>DvMF_2895 methyl-viologen-reducing hydrogenase delta subunit (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MATKIGVYFDQSSIGGGLDLESLADTVGGKWGDLTPVCKVFPILADKKARDEIVADIEEE
GLDGVLLCGASPRVDWDLYEFEGVLVDRVNLREQGVMSYKNPDGSLADPEAAPQLLEMLV
TDYVNMGVVRLQKTTAPDGSPSEGVRRILVLGGGWTGLTAAVNGSLAGHEVVLVEKDEVL
GGRALGLLKTVPLSHPYTDVHDTGIEKKIAAVQADDNITVYTKAKLAKLSGQPGDFTATI
ALASGEQEVKVGAVVLATGWQPQDTKVLEPFGYGSLQNVVTAAEFEKMAKTGTITARRVA
FILNTALAEPADPYAELCAPEAPADAPAPAEGEAAAPAVKDHESVRHLPISNAISSVVAL
KQAGYVCDAFDGGQAFILYDSMVVQGIHERFYKAAQDRLGVMMSKAEIRSITQAADGSLN
VLCDKTLIGDDIEINVDMVVLPTGIVPATAKDPIVNFDYRQGPAFPDLELFEGYADSNYI
CFPYETRRTGVYAAGCVRQPMMLDAAEEDAVGATMKAIQCIESANKGVAVHPRSGDLSYP
LFNFVRCTQCKRCTEECPFGALDDDEKGTPKPNPARCRRCGTCMGACPERVISFANYNVD
QIGSMIREINVPPDMKKGGPRVVILACENDAYPALDMAALRGKHWSPYVRIIPVRCLGSV
NAIWVADAMSKGIDGVMMLGCKYGDDYQCHFVKGSEICKRRKENIAETLNRLGVEPDRVE
QYEVAIDEYDKLPGVIEDFMNMILEKGPNPFKGY