Protein Info for DvMF_2894 in Desulfovibrio vulgaris Miyazaki F

Annotation: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 412 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details PF00070: Pyr_redox" amino acids 4 to 94 (91 residues), 22.4 bits, see alignment E=6.7e-08 PF00890: FAD_binding_2" amino acids 5 to 40 (36 residues), 30 bits, see alignment 1.5e-10 PF12831: FAD_oxidored" amino acids 5 to 41 (37 residues), 37.3 bits, see alignment 9.6e-13 PF01134: GIDA" amino acids 5 to 87 (83 residues), 20.5 bits, see alignment E=1e-07 PF13450: NAD_binding_8" amino acids 7 to 43 (37 residues), 32.8 bits, see alignment 3e-11

Best Hits

KEGG orthology group: K03388, heterodisulfide reductase subunit A [EC: 1.8.98.1] (inferred from 100% identity to dvm:DvMF_2894)

MetaCyc: 70% identical to QmoA (Desulfovibrio desulfuricans)
RXN-23227

Predicted SEED Role

"CoB--CoM heterodisulfide reductase subunit A (EC 1.8.98.1)" in subsystem Anaerobic respiratory reductases or H2:CoM-S-S-HTP oxidoreductase or Methanogenesis (EC 1.8.98.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.8.98.1

Use Curated BLAST to search for 1.8.98.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8DS76 at UniProt or InterPro

Protein Sequence (412 amino acids)

>DvMF_2894 FAD-dependent pyridine nucleotide-disulphide oxidoreductase (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MSNSILVVGGGFSGLTAAIEAAEVGYEVYIVEKTPFLGGRVAQLNKYFPKLCPPSCGLEI
QFQRIKKNPRIKFFTQAEVTAVSGDAGNYTVKVHIEPRGTVPSSADLSLLASSLESDVDN
EFELGLAKRKPLYMSVPFAFPSRFVLDKAALSRADELKVGKSAFCDMNEAPRDIELNVGS
IVVATGWKPYDVTKLSNLGAGAFANCVSNMQLERLASASGPTAGQIKRPSDGKAPKKVAF
VQCAGSRDQNHLNYCSYICCMASLKQALYVREQYPDAEVTVYYIDLRTPGRYDKFLRKVK
ADEKIALVKGKVAGVEEDAATGDVIVEVEDAVKGEKRKYRYDLVVLATGMQPSLAGQKLP
FDVPVDEEGFIVGGEEKGIFAAGCAQKPLDVMRTAQSGTSAALKAIQTVRGR