Protein Info for DvMF_2893 in Desulfovibrio vulgaris Miyazaki F
Annotation: adenylylsulfate reductase subunit alpha (RefSeq)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 89% identical to APRA_DESGG: Adenylylsulfate reductase subunit alpha (aprA) from Desulfovibrio gigas (strain ATCC 19364 / DSM 1382 / NCIMB 9332 / VKM B-1759)
KEGG orthology group: K00394, adenylylsulfate reductase, subunit A [EC: 1.8.99.2] (inferred from 100% identity to dvm:DvMF_2893)MetaCyc: 59% identical to APS reductase alpha subunit (Thiobacillus denitrificans)
Adenylyl-sulfate reductase. [EC: 1.8.99.2]
Predicted SEED Role
"Adenylylsulfate reductase alpha-subunit (EC 1.8.99.2)" in subsystem Anaerobic respiratory reductases (EC 1.8.99.2)
MetaCyc Pathways
- dissimilatory sulfate reduction I (to hydrogen sufide)) (5/5 steps found)
- sulfite oxidation III (2/3 steps found)
- superpathway of thiosulfate metabolism (Desulfovibrio sulfodismutans) (4/6 steps found)
- sulfite oxidation II (1/3 steps found)
- superpathway of sulfur metabolism (Desulfocapsa sulfoexigens) (2/6 steps found)
- superpathway of sulfide oxidation (phototrophic sulfur bacteria) (4/12 steps found)
- superpathway of sulfur oxidation (Acidianus ambivalens) (1/9 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.8.99.2
Use Curated BLAST to search for 1.8.99.2
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See B8DS75 at UniProt or InterPro
Protein Sequence (665 amino acids)
>DvMF_2893 adenylylsulfate reductase subunit alpha (RefSeq) (Desulfovibrio vulgaris Miyazaki F) MPMIPVKEQPKGVAIADPIVKEHDVDILIVGGGMGSCGTAFEVVRWADKYAPDLKIMLLD KATLERSGAVAQGLSAINTYLGKNPADDYVRMVRTDLMGLVREDLIFDLGRHVDDSVHLF EEWGLPCWIKDEHGHNLDGAQAKAAGKSLRAGDDPVRSGRWQIMINGESYKCIVAEAAKN ALGEARIMERIFIVKLLLDANTDNRIAGAVGFNLRENEVHIFRTNAMMVACGGAVNVYKP RSTGEGMGRAWYPVWNAGSTYTMCAQVGAEMTMMENRFVPARFKDGYGPVGAWFLLFKAK ATNYKGEDYCATNRAMLKPYEDRGYAKGHVIPTCLRNHMMLREMREGRGPIYMDTKTALQ NTFATMTPEQQKHLESEAWEDFLDMCVGQANLWASMNIQPEERGSEIMPTEPYLLGSHSG CCGIWVSGPDEAWVPEDYKVRADNGKVYNRMTTVMGLWTCADGVGASGHKFSSGSHAEGR ICGKQMVRWCIDHKDFKPAIKETAEELKQLIYRPYYNYLAGKDASTDPVVNPTYISPKNF MMRLVKCTDEYGGGCGTYYTTSAAALDTGFALMDMMEEDSLKLAARDLHELLRCWENYHR LWTVRLHMQHIRFREESRYPGFYYRADFMGLDDSKWKCFVNSKHDPKKGETKIFKKPYYQ IIPTE