Protein Info for DvMF_2851 in Desulfovibrio vulgaris Miyazaki F

Annotation: diguanylate cyclase and serine/threonine protein kinase with TPR repeats (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 807 PF00990: GGDEF" amino acids 103 to 252 (150 residues), 38.5 bits, see alignment E=7.1e-13 PF13432: TPR_16" amino acids 620 to 673 (54 residues), 24.9 bits, see alignment 1.6e-08 amino acids 654 to 708 (55 residues), 23.1 bits, see alignment 6.4e-08 amino acids 716 to 760 (45 residues), 17.2 bits, see alignment 4.2e-06 PF07721: TPR_4" amino acids 641 to 665 (25 residues), 11.3 bits, see alignment (E = 0.00035) amino acids 711 to 734 (24 residues), 19.6 bits, see alignment (E = 7.5e-07) PF13174: TPR_6" amino acids 643 to 673 (31 residues), 14.8 bits, see alignment (E = 2.7e-05) PF13424: TPR_12" amino acids 643 to 704 (62 residues), 30.3 bits, see alignment 2.7e-10 PF13181: TPR_8" amino acids 643 to 673 (31 residues), 17.5 bits, see alignment (E = 2.5e-06) amino acids 677 to 705 (29 residues), 15.6 bits, see alignment (E = 1e-05) PF14559: TPR_19" amino acids 688 to 752 (65 residues), 39.5 bits, see alignment E=4.2e-13 PF07719: TPR_2" amino acids 710 to 742 (33 residues), 25.7 bits, see alignment (E = 5.9e-09) PF13176: TPR_7" amino acids 711 to 743 (33 residues), 19.1 bits, see alignment (E = 7.4e-07) PF13428: TPR_14" amino acids 714 to 752 (39 residues), 27.5 bits, see alignment 2.5e-09

Best Hits

KEGG orthology group: None (inferred from 100% identity to dvm:DvMF_2851)

Predicted SEED Role

"TPR repeat"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8DRF1 at UniProt or InterPro

Protein Sequence (807 amino acids)

>DvMF_2851 diguanylate cyclase and serine/threonine protein kinase with TPR repeats (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MWQVPLTRRDLIAFEHRLRDAMARVLPFKAYSLYFPRAASGPEPLWLPQERKLLVPLMHQ
GQQLGVFVARGVPARTARALSPVLPGVAGLCLENLQLYKASLTDPVTGLATRQHLLDAIA
REVDCIRDCFSTASEGKCDLAAGHRASMGVIAVRLGSLREVARDHGYVFADRLIAALAEE
LRRAAPEQALAARTGDFEFALFVPAGTSGGCRKLAVDMVRRLRGVTITCGLTEEPVGVAV
SAGFAVYPQDMEGAAFARDHGEQARVLLRKARLAAAVAVEAAALSVPSAGEGDGKGGDAA
PGVPVMGFSRILAEGGRVLETLPLSRVVLSLGGNMNAREGQRFSVWSVAYPVRGGSQEPR
QPLYKGEVVLMEVRDNTSLAEIMHVGDPTWPVEPGDRLTLLPEEKGVTVRDGGGEAPRTD
PLTGLFRHGDFLARWSAERERCDGFALALIRLSDEGREPEGRAAHPEQLMAEAAQLCRDL
LGPQALGGRYGLNSLIFFHPGMTADGTEGAQGARETYAALCDELERRLRIGAAVGVACHP
YLSYRKADALENCLKALEYAMLLPAPRVGVLDSLALNISADKRYSLGDTFGAIEEYKLAL
LADEGNTMAWNSLGVCMAGLGRHSEARRHFGEALARKPGDPMALYNLGTVCQSEGEAAEA
RDCFRKCLRNAPGHVYALIRLGQLAEGEKRFAQARQYYTKAAKLDGGAALTCRHLARLCM
RQGRPDEAREHLHEALLHNPQDAIALQLMARLYLDGGEDPEIAEVMARQSVALRPDLKQG
WLELARALQVRGRDHDAREALLRAGER