Protein Info for DvMF_2659 in Desulfovibrio vulgaris Miyazaki F
Annotation: cysteine desulfurase NifS (RefSeq)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 63% identical to NIFS_TRIAZ: Cysteine desulfurase (nifS) from Trichormus azollae
KEGG orthology group: K04487, cysteine desulfurase [EC: 2.8.1.7] (inferred from 100% identity to dvm:DvMF_2659)MetaCyc: 49% identical to mitochondrial cysteine desulfurase NFS1 (Homo sapiens)
Cysteine desulfurase. [EC: 2.8.1.7]; 2.8.1.7 [EC: 2.8.1.7]; 2.8.1.7 [EC: 2.8.1.7]; 2.8.1.7 [EC: 2.8.1.7]
Predicted SEED Role
"Cysteine desulfurase (EC 2.8.1.7), NifS subfamily" in subsystem Alanine biosynthesis or Nitrogen fixation (EC 2.8.1.7)
MetaCyc Pathways
- superpathway of thiamine diphosphate biosynthesis II (9/11 steps found)
- superpathway of thiamine diphosphate biosynthesis I (8/10 steps found)
- L-alanine biosynthesis III (1/1 steps found)
- L-cysteine degradation IV (1/1 steps found)
- superpathway of L-alanine biosynthesis (3/4 steps found)
- thiazole component of thiamine diphosphate biosynthesis II (5/7 steps found)
- thiazole component of thiamine diphosphate biosynthesis I (4/6 steps found)
- cytidylyl molybdenum cofactor sulfurylation (1/2 steps found)
- bis(guanylyl molybdopterin) cofactor sulfurylation (1/3 steps found)
- tRNA-uridine 2-thiolation (thermophilic bacteria) (2/5 steps found)
- tRNA-uridine 2-thiolation (mammalian mitochondria) (1/4 steps found)
- tRNA-uridine 2-thiolation (yeast mitochondria) (1/4 steps found)
- molybdopterin biosynthesis (2/6 steps found)
- tRNA-uridine 2-thiolation (cytoplasmic) (1/8 steps found)
- [2Fe-2S] iron-sulfur cluster biosynthesis (2/10 steps found)
- tRNA-uridine 2-thiolation and selenation (bacteria) (2/11 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 2.8.1.7
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See B8DIT7 at UniProt or InterPro
Protein Sequence (404 amino acids)
>DvMF_2659 cysteine desulfurase NifS (RefSeq) (Desulfovibrio vulgaris Miyazaki F) MNTVYFDNNATTRVDPAVLAAMLPYFGELYGNPSSMHTFGGHVGRAVREAREQVARLIGA TPEEIVFTSCGTEGDNTAIRAALAAQPEKKHIITTRVEHPAVLSLSQHLEKNGYELTLLG VDDKGRMDLDELREAIRKDTAIVSIMFANNETGTIFPVAEAAAICKERGVPFHTDAVQAV GKLAIDVRELPVDYLVLSGHKLHAPKGIGALYVRRGAAYRPFLRGGHQERGRRGGTENVP AIIGLGMACDLAAANMAEENTRVRALRDRLEQGLLAAIPDAIVNGDPANRLPNTTNISFK YVEGEAILLLLDQLGVCASSGSACTSGSLEPSHVLRAMGVPFTYAHGSIRFSLSRFNTQE EVDHVVRELPRVIARLREMSPFRAGSEAEAALCKPDRSCQGCGS