Protein Info for DvMF_2630 in Desulfovibrio vulgaris Miyazaki F

Annotation: penicillin-binding protein, 1A family (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00912: Transgly
  • amino acids 57 to 230 (174 residues), 223 bits, E=3.9e-70
• TIGR02074: penicillin-binding protein, 1A family
  • amino acids 66 to 734 (669 residues), 611.5 bits, E=7.9e-188
• PF17092: PCB_OB
  • amino acids 333 to 459 (127 residues), 60.3 bits, E=6.1e-20
• PF00575: S1
  • amino acids 362 to 427 (66 residues), 22.9 bits, E=1.9e-08
• PF00905: Transpeptidase
  • amino acids 461 to 724 (264 residues), 118 bits, E=9.9e-38

Best Hits

KEGG orthology group: K05366, penicillin-binding protein 1A [EC: 2.4.1.- 3.4.-.-] (inferred from 100% identity to dvm:DvMF_2630)

Predicted SEED Role

"Multimodular transpeptidase-transglycosylase (EC 2.4.1.129) (EC 3.4.-.-)" in subsystem Peptidoglycan Biosynthesis or Type IV pilus (EC 2.4.1.129, EC 3.4.-.-)

MetaCyc Pathways

• peptidoglycan biosynthesis I (meso-diaminopimelate containing) (11/12 steps found)
• peptidoglycan biosynthesis III (mycobacteria) (11/15 steps found)
• peptidoglycan biosynthesis II (staphylococci) (12/17 steps found)
• peptidoglycan biosynthesis IV (Enterococcus faecium) (12/17 steps found)
• peptidoglycan biosynthesis V (β-lactam resistance) (11/17 steps found)
• peptidoglycan maturation (meso-diaminopimelate containing) (3/12 steps found)

KEGG Metabolic Maps

• Anthocyanin biosynthesis
• Biotin metabolism
• Carotenoid biosynthesis - General
• Flavone and flavonol biosynthesis
• Flavonoid biosynthesis
• Fructose and mannose metabolism
• Glycerolipid metabolism
• Glycosphingolipid biosynthesis - ganglio series
• Glycosphingolipid biosynthesis - globo series
• Glycosphingolipid biosynthesis - lacto and neolacto series
• Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
• High-mannose type N-glycan biosynthesis
• Keratan sulfate biosynthesis
• Lipopolysaccharide biosynthesis
• Lysine degradation
• N-Glycan biosynthesis
• O-Glycan biosynthesis
• O-Mannosyl glycan biosynthesis
• Peptidoglycan biosynthesis
• Sphingolipid metabolism
• Zeatin biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 2.4.1.-, 2.4.1.129, 3.4.-.-

Use Curated BLAST to search for 2.4.1.- or 2.4.1.129 or 3.4.-.-

Sequence Analysis Tools

See B8DIQ8 at UniProt or InterPro

Protein Sequence (807 amino acids)

>DvMF_2630 penicillin-binding protein, 1A family (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MKKLLLTLGIVGALGIAAAAGLAAMLVVWASHDLPSFTRIADYRPPLVTTVYARDGSVMG
YFYREKRFLAPLDKMSPRVPQAFLAAEDDGFYRHEGIDPIAIFRAFLKNMQAGSIKQGGS
TITQQIVKRLLLTSEKSYERKIKEAILAYRLEKYLSKDEILTIYLNQIYLGGGAYGVEAA
ARTYFGKHVNELSLAEAAVIGGLPQAPSKYNPFRDPDATRQRQMYVLHRMLDLGWINRAE
YDEAVAQPLVYRSMDDSGWREGAWYLEEVRRQLIDFFSEANVKRLGLKVDRYGEDAIYEL
GLHVRTSMEPLHQSAAEKALRNGLNDASHRHGWRGPLQRLKPTEYDAFLKHENFTPAALA
DGAWARALVTKVVPQGAEVRLGGYRGFIDVKSMAWCRTPDIRYAPENVAAVKDAKKVLDV
GDVVWVSALGADGKAASYNPSLVSQAGVIQLSLEQYPDVQGAVVTIEPDTGDVLALVGGY
SFSDSQFNRAIQARRQPGSSFKPIVYSAAMDHGFTAGSVVLDAPFVYLNEYTDKIWRPEN
FEGVFYGPTLLRTALAKSRNLCTIRVAQKIGIPAVIERATALGLEGPFPNELSVSLGAVA
VSPINMAEAYTAFAAEGRVAKRRFIHSIGDAWGETLFESKPDVREVLSPQNAFIMATLMK
EVVQDGTATKAKVLGKPLAGKTGTTNDERDAWFIGYTPHLVTAVYVGFDQVAPMGKFETG
GRAALPIFVDYRKVVEPKYPADDFPMPPGIVMVRVDGKTGQIAGPGSETSYLLPFQLGTQ
PTSTAGDPVHRGDDDTKSAEDLLKQLY