Protein Info for DvMF_2371 in Desulfovibrio vulgaris Miyazaki F

Annotation: 3-deoxy-manno-octulosonate cytidylyltransferase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 270 PF02348: CTP_transf_3" amino acids 9 to 238 (230 residues), 169.9 bits, see alignment E=7.1e-54 TIGR00466: 3-deoxy-D-manno-octulosonate cytidylyltransferase" amino acids 10 to 258 (249 residues), 214.8 bits, see alignment E=6e-68 PF12804: NTP_transf_3" amino acids 17 to 137 (121 residues), 30.9 bits, see alignment E=2.9e-11

Best Hits

Swiss-Prot: 100% identical to KDSB_DESVM: 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB) from Desulfovibrio vulgaris (strain Miyazaki F / DSM 19637)

KEGG orthology group: K00979, 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) [EC: 2.7.7.38] (inferred from 100% identity to dvm:DvMF_2371)

Predicted SEED Role

"3-deoxy-manno-octulosonate cytidylyltransferase (EC 2.7.7.38)" in subsystem KDO2-Lipid A biosynthesis (EC 2.7.7.38)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.38

Use Curated BLAST to search for 2.7.7.38

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8DIL4 at UniProt or InterPro

Protein Sequence (270 amino acids)

>DvMF_2371 3-deoxy-manno-octulosonate cytidylyltransferase (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MTAFPTCYGIIPARYASSRFPGKPLADIAGMPMFWHVYQRAARCPELCKVVLATDDERIA
QAAHRLDVPFVMTRPDHESGTDRVYEAACLLGRDLESSGKAGLPDDAVVVNIQGDEPALD
PRMLSQLVAPFTAAKDGARVRVATLAMAIDAAEAASPDRVKVVTAVNGDALYFSRAAIPF
ARDGGVQAGDAAAGPAYLGHVGLYAFRLEALRAFTQLAPSSLERREKLEQLRLLENGIPI
RVVPTTYRTHGVDRPEDIGIIINLLGENEG