Protein Info for DvMF_2273 in Desulfovibrio vulgaris Miyazaki F

Annotation: PAS/PAC sensor hybrid histidine kinase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1223 transmembrane" amino acids 36 to 58 (23 residues), see Phobius details amino acids 430 to 450 (21 residues), see Phobius details PF00672: HAMP" amino acids 448 to 500 (53 residues), 48.7 bits, see alignment (E = 3.1e-16) TIGR00229: PAS domain S-box protein" amino acids 537 to 658 (122 residues), 51.5 bits, see alignment E=5.5e-18 PF00989: PAS" amino acids 539 to 650 (112 residues), 34.1 bits, see alignment E=9.4e-12 PF13426: PAS_9" amino acids 551 to 652 (102 residues), 33.1 bits, see alignment E=2.3e-11 PF00512: HisKA" amino acids 672 to 737 (66 residues), 70.5 bits, see alignment 4e-23 PF02518: HATPase_c" amino acids 861 to 937 (77 residues), 81.4 bits, see alignment 2.6e-26 PF00072: Response_reg" amino acids 1066 to 1178 (113 residues), 76.4 bits, see alignment E=7.8e-25

Best Hits

KEGG orthology group: None (inferred from 100% identity to dvm:DvMF_2273)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8DQU7 at UniProt or InterPro

Protein Sequence (1223 amino acids)

>DvMF_2273 PAS/PAC sensor hybrid histidine kinase (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MMGPLRTTLARCWARFPLRPLLRHVVPPAPGLRLRMVGWCSLVCLLPLGIVSAVFVQVTT
VQTDSYLHAQGRTLADAASLQLTRLSRTAEALARVVAGLRVEYDGDMPGLRLRLSELHGL
WPRACIEVFDMGAEPVVRLLPASGGPERLAGGVTPNGATTDGALVVRQALRGLTRRDVFR
SADGLAIKAVVPIIVPLEQAGARHGGKIRRPLPTPMGPASLPESSLGGMVPLPPQMSLPS
QMEQAPYAPFASDAEEITGQADLEGLAARQHGRIVGAAVVSFPMNRSLLRGLGDAVRADV
AVFDLGGERPRGTLFPGDGTADVADWPDRPDLAQGASPGGLAGGGVAGGAHSGTGASGGN
VSGGGFFGRAQGFGQAQGLPFLQRYEQVAGKPYLVSYQPLPGGSGMPVGALAVFVDVEPQ
RSRLRTAVEYTLLAAVVALGLSLCTGFLIADRVVRPLHELLHAIRRISLGNYSERLPPAG
MAEIGQLAQAVNHMASTLEENRTSLLGALQEKVESGERLARANRELELLNWELTRAQANY
RRIFEESAQGIYQSTPQGRFLRTNPAMARMFGYSSPYEMVSSVTDIGEQFYVRPGEREEL
LRRLRQEGRVSLETCLRRRDASVVHVALTARAVTGETGEQLYIEGAVHDITERVERHRAE
REREAAEAASRAKTQLLARMSHEVRTPLNALLGMADVLDRTPLEPEQRGYLDVLRNSGHS
LLALLNDVLDFSRLEAGRVVPERVGFRLGEIMAQVCRQMEPAASADGRGLRLDWAVLPGV
PDALVGDPLRLRQILGNLVSNAVKFTPAGRVMVLAQPADGNVPDRDAGPVASPVASPVAH
PATPSASPDEAPCRPSSGRRMEVLFSVADTGIGIPPEHQDVVFESFMQADSSITRQYGGT
GLGLSICRALVEMLGGAIWLESAPGRGTTVYFTLPMQPAGEAVCGPNPAVPANLAAPAET
RTPGASEPSEGTVMPVSPAASGAAVPLSARDVPTDARASVQAYPVIPVTPVTPVTPGDAV
VRVGGAATEGGAVTGAAGLAETPVPPDLPDARLGDEDSGPQRSLSILLVEDSPSNRLLFS
LYLRGRPCAITEVHNGEEGVAAYATGRFDLVFMDIEMPVLDGYRATRAIRALERERGLPP
TPIIALTAHVVGEFRNDCAAAGCTGFLAKPFSRGELLRCMARHCGGGDAAGDAWQAGSDL
AGGSDFTEGAGSPAGNQSSPGPE