Protein Info for DvMF_2233 in Desulfovibrio vulgaris Miyazaki F

Annotation: carbon-monoxide dehydrogenase, catalytic subunit (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 629 TIGR01702: carbon-monoxide dehydrogenase, catalytic subunit" amino acids 15 to 627 (613 residues), 695.1 bits, see alignment E=3.7e-213 PF03063: Prismane" amino acids 50 to 607 (558 residues), 593.3 bits, see alignment E=2.1e-182

Best Hits

Swiss-Prot: 53% identical to COOS1_METAC: Carbon monoxide dehydrogenase 1 (cooS1) from Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)

KEGG orthology group: K00198, carbon-monoxide dehydrogenase catalytic subunit [EC: 1.2.99.2] (inferred from 100% identity to dvm:DvMF_2233)

Predicted SEED Role

"Carbon monoxide dehydrogenase CooS subunit (EC 1.2.99.2)" in subsystem Carbon monoxide induced hydrogenase (EC 1.2.99.2)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.2.99.2

Use Curated BLAST to search for 1.2.99.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8DQQ7 at UniProt or InterPro

Protein Sequence (629 amino acids)

>DvMF_2233 carbon-monoxide dehydrogenase, catalytic subunit (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MNSGTPDTERTLWEDARQMLRKAEAENIPTAWDRMREQTPHCKFCELGTTCRNCVMGPCR
IANRKDGKMRYGVCGADADVIVARNFGRFIAGGAAGHSDHGRDLIETLEAVVEGHAPGYT
IRDEAKLRRIAGELGVADADTRPTLDVARDLVDVCYADFGSRRTELAFLKRAPKARRELW
ARLGMTPRGIDREIAEMMHRTHMGCDNDPASLLTHAARTALADGWGGSMIGTELSDILFG
TPMPRQSTVNLGVLREDAVNILVHGHNPVVSEMILAAAREPAMQQAARDAGAAALNVAGL
CCTGNELLMRQGIPMAGNHLMTELAIVTGAADAIVADYQCIMPSLVRIAACYHTRFVTTS
SKGRFTGATHIEVHPHNAQEKCREIVQLAIEAFTRRDPARVSIPVQPVPITTGFSNEAIL
AALGGTPAPLLDAVKAGQIRGFVGIVGCNNPKIMQDSGNVGLAKELIRRDIMVLATGCVT
TAAGKAGLLMPEAADMAGPGLSAVCKALGVPPVLHMGSCVDNSRILQLCGLLADELGVDI
SDLPVGASSPEWYSEKAAAIGLYAVASGIPTHLGLPPNILGSDVVTGMAVDGLNGLVGAA
FMVEADPVKAADLLEAHIVARRQKLGLSA